Seroprevalence of Anti-HCV, HbsAg and HIV Antibodies in Patients Undergoing Hemodialysis in a Tertiary Care Centre
Keywords:HBV, HCV, anti-HCV, HBsAg, HIV, CKD, Seroprevalence, Hemodialysis.
Background: Hepatitis C virus (HCV), Hepatitis B virus (HBV) and Human Immunodeficiency virus (HIV)
infections are important causes of morbidity and mortality in Hemodialysis patients. Patients on Hemodialysis
may be infected through blood transfusion, contamination of dialysis machines and equipments as well as
interpersonal horizontal transmission in dialysis units. Studies on seroprevalence of HCV, HBV and HIV in
Hemodialysis patients are limited in India.
Objective: The present study was carried out to see the seroprevalence of anti-HCV, HBsAg and HIV
antibodies in patients on Hemodialysis.
Method: 100 patients undergoing Hemodialysis were included in the study. Patient’s history was taken
regarding the blood transfusion, high-risk behavior, duration on dialysis and others. With the informed
consent of the patients, blood was drawn; serum was separated and subjected to screening for the presence
of anti-HCV, HBsAg and HIV antibodies. Healthy individuals included as controls in the study were
simultaneously screened for anti-HCV, HBsAg and HIV antibodies.
Results: In our study, a total of 100 patients undergoing Hemodialysis were screened, out of which 11(11%)
were anti-HCV positive and none of them were positive for HBsAg and HIV antibodies. Maximum numbers
of patients undergoing Hemodialysis were in the age group of 41-50 years 36(36%). All the 100 patients
undergoing Hemodialysis were diagnosed to be having Chronic Kidney Disease (CKD). It is been observed
that number of blood transfusions and number of Hemodialysis sessions in the given period of time were
more in anti-HCV positive patients when compared to anti-HCV negative patients.
Interpretation and conclusion: In the present study, HCV infection is more prevalent among Hemodialysis
patients. HCV infection prominently increases the burden of disease in the Hemodialysis population. The
longer the patient is on Hemodialysis, the more susceptible he/she is to HCV acquisition. Hemodialysis
patients should be routinely screened for HCV infection, preferably using serological methods.