Association of Glycated Hemoglobin and Dyslipidemia Inpatients with Type 2 Diabetes Mellitus in a K.M.C.H. Katihar, Bihar-A Retrospective, Cross-Sectional and Descriptive Study

Authors

  • Amresh Kumar
  • Jiut Ram Keshari
  • Manish Kumar

DOI:

https://doi.org/10.37506/ijocm.v9i1.2932

Keywords:

Cholesterol, Diabetes mellitus, Dyslipidemia, Glycated hemoglobin, High-density lipoprotein cholesterol, Low-density lipoprotein cholesterol, Triglycerides

Abstract

Introduction: Dyslipidemia is one of the major risk factors for cardiovascular disease in diabetes
mellitusType2.The aim of the study was to understand the pattern of dyslipidemia and its association with
glycated hemoglobin (HBA1C) among Type 2 diabetic.
Materials and Methods: This was a retrospective cross-sectional study to assess the relationship between
glycemic control (as reflected by HBA1C) and serum lipid profile in Type2 diabetic patients which included
a total of 200 Type2 diabetic patients (104 males; 96 females; mean age years 62.91). Venous blood samples
were collected from all the patients after at least 8 h fasting.
Results: HBA1C, fasting blood glucose (FBG), total cholesterol, triglycerides (TG), high-density lipoprotein
(HDL) cholesterol, and low-density lipoprotein (LDL) cholesterol were analyzed. In male and female
patient, serum levels of HBA1C, FBG, and LDL were not significantly different. As compared to males,
female patients showed significantly higher serum cholesterol and HDL but significantly lower TG levels.
Correlation between HBA1C and FBG was highly significant in this study. Both HBA1C and FBG exhibited
direct correlations with cholesterol, TG, and LDL and inverse correlation with HDL; the magnitude of
significance for all these lipid parameters being greater with HBAIC than FBG. There was a linear
relationship between HBA1C and dyslipidemia. The levels of serum cholesterol and TG were significantly
higher and of HDL significantly lower in patients with worse glycemic control as compared to patients with
good glycemic control.
Conclusion: The findings of this study clearly showed that HBA1C is not only a useful biomarker of longterm
glycemic control but also a good predictor of lipid profile.

Author Biographies

Amresh Kumar

Assistant Professor, Dept. of Biochemistry, DMCH, Laheriasarai, Darbhanga

Jiut Ram Keshari

Additional Professor, Dept. of Biochemistry, IGIMS, Patna

Manish Kumar

Professor, Department of Physiology, IGIMS, Patna

Published

2021-03-30