Correlation between IL-10 Expression with Histopathology Type on Nasopharyngeal Carcinoma Patients

  • Hamita1, Widodo Ario Kentjono1, H.M.S. wiyadi1
Keywords: Nasopharyngeal Carcinoma, Expression IL-10, Histopathological Type

Abstract

Background: Nasopharyngeal carcinoma (NPC) is a malignancy derived from lymphoepithelial tissue and
nasopharyngeal epithelial cells. The response therapy of NPC evaluated from histopathological type, but in
some patients with the same type was illustrated a different response of therapy. IL-10 expression expects to
predict a better response therapy of NPC. IL-10 expression by immunohistochemical examination associated
with the differentiation of tumors.
Method: The study was analytic observational with the cross-sectional approach. Samples were collected
by consecutive sampling and formalin-fixed, paraffin-embedded biopsy specimens were obtained.
Result: The result of IL-10 expression in Nasopharyngeal carcinoma (NPC) patients with histopathological
World health organization (WHO) type I was obtained; From all the samples, there were 36.36% of strong
positive expression and 63.64% of frail positive expression. There were increases in the number of cells that
give a strong expression on WHO type III. Statistical analysis using Fisher’s exact test was obtained p =
0.040 with a contingency coefficient of 0.384.
Conclusion: There was a moderate correlation between IL-10 expression and histopathological type in NPC
patients.

Author Biography

Hamita1, Widodo Ario Kentjono1, H.M.S. wiyadi1

1Department of Otolaryngology and Neurology, Faculty of Medicine, Universitas Airlangga,
Dr. Soetomo Teaching Hospital, Surabaya 60285, Indonesia

Published
2020-05-22
How to Cite
Hamita1, Widodo Ario Kentjono1, H.M.S. wiyadi1. (2020). Correlation between IL-10 Expression with Histopathology Type on Nasopharyngeal Carcinoma Patients. Medico Legal Update, 20(2), 250-254. Retrieved from http://ijop.net/index.php/mlu/article/view/1111