Evaluation of Reproductive Hormones in Patients with β-Thalassemia Major in Misan Province, Iraq

  • Tutor Noor AL-Huda Salah AL-Zuhairy1, Zainab Abdul Jabbar Ridha AL-Ali2
Keywords: β-thalassemia major, serum ferritin, reproductive hormones.

Abstract

Assessment of serum ferritin, FSH, LH, estradiol, testosterone levels in β-thalassemia major patients. A total
50 (30 male and 20 female) children with β- thalassemia major patients with ages range 11- 16 years and 50
age and sex matched healthy adolescents as control group were included in this study. The study subjects
divided into 2 more subgroups: 11-13 years, and 14-16 years to measure mean serum ferritin, FSH, LH,
testosterone, estradiol hormones. There was significant increase (P <0.05) in serum ferritin level in male
and female patients as compared to control groups. Male patients have significant decreased (P<0.05)serum
levels of FSH, LH, testosterone and estradiol, while female patients have non-significant (P >0.05) high
serum FSH and testosterone levels, but LH, estradiol levels were non-significant (P>0.05) lowas compared
to control. In age subgroup 11–13 years, male patients have significant (P<0.05) decreased reproductive
hormones levels as compared to control, however in 14 – 16 years subgroups serum FSH,LH and estradiol
levels in male patients were significantly decreased as compared to control (P<0.05), whereas,hormones
levels in female patients didn’t show significant differences in comparison to female control in both age
subgroups (P>0.05). Serum ferritin had an inverse correlation with serum FSH, LH, testosterone, estradiol
hormones levels. Patients with β- thalassemia major have iron overload with inverse correlation between
gonadal hormones and serum ferritin.

Author Biography

Tutor Noor AL-Huda Salah AL-Zuhairy1, Zainab Abdul Jabbar Ridha AL-Ali2

1Department of Biology, College of Science, University of Misan, Maysan, Iraq, 2Prof., Department of Biology,
College of Science, University of Misan, Maysan, Iraq

Published
2020-05-22
How to Cite
Tutor Noor AL-Huda Salah AL-Zuhairy1, Zainab Abdul Jabbar Ridha AL-Ali2. (2020). Evaluation of Reproductive Hormones in Patients with β-Thalassemia Major in Misan Province, Iraq. Medico Legal Update, 20(2), 274-279. Retrieved from http://ijop.net/index.php/mlu/article/view/1115