One-Pot Synthesis of New Pyrazolo [3, 4, -d] Pyrimidine Derivatives and Study of their Antioxidant and Anticancer Activities

  • Ahmed A. Hadi1, Zainab Y. Kadhim2, Ameena N. Seewan1, Murad G. Munahi3, Mohammed Qasim Waheeb4
Keywords: Pyrazole, Pyrimidine, anticancer, antioxidant DPPH; MCF-7.

Abstract

An effort was made to synthesize a new series of pyrazolo [3,4-d] pyrimidine derivatives (2-5). The synthesis
of these compounds was achieved via reaction of 3-methyl-1,4-dihydropyrazol-5-one (1) with a substituted
aromatic aldehyde and urea or thiourea in mild reaction conditions, giving satisfactory yields. FT-IR and
1H-NMR spectroscopies were used to characterize the structure of the newly synthesized compounds (2-
5), where the spectral data confirmed the formation of these compounds. The antioxidant activity of these
compounds (2-5) was examined in this study the synthesized compounds showed a moderate-high antioxidant
effect, which was examined by using 1, 1-diphenyl-2-picrylhydrazyl (DPPH) free radical scavenging assays.
The cellular toxicity of the compounds (2-5) was studied on MCF-7 cell lines using MTT assay. Compound
(5) showed the highest toxicitytowards MCF-7 cell lines.

Author Biography

Ahmed A. Hadi1, Zainab Y. Kadhim2, Ameena N. Seewan1, Murad G. Munahi3, Mohammed Qasim Waheeb4

1Lecturer, Department of Science, College of Basic Education, 2Lecturer, Department of Chemistry, College of
Veterinary Medicine, 3Lecturer, Department of Chemistry,College of Science, 4Assistant Professor, Department of
Biology, College of Science, Al Muthanna University, Iraq

Published
2020-05-22
How to Cite
Ahmed A. Hadi1, Zainab Y. Kadhim2, Ameena N. Seewan1, Murad G. Munahi3, Mohammed Qasim Waheeb4. (2020). One-Pot Synthesis of New Pyrazolo [3, 4, -d] Pyrimidine Derivatives and Study of their Antioxidant and Anticancer Activities. Medico Legal Update, 20(2), 326-331. Retrieved from http://ijop.net/index.php/mlu/article/view/1124