Pesticides: Slow but Silent Killer

  • Gauri Joshi1, A.G. Joshi2, Ajit Sontakke3, Sangita Patil4, Dhirajkumar Mane4, K.C. Wingakar5
Keywords: Pesticides, Free radicals, oxidative stress, lipid peroxidation, antioxidant

Abstract

Introduction: Abundant use of organophosphates, carbamates, organochlorides and pyrethroid pesticides
develop several hazardous health effects on nervous, respiratory, endocrine, reproductive and immune
systems of humans as well as animals. All these effects of pesticides are due to generation of oxidative
stress, either by producing free radicals or by developing variations in antioxidant status.
Objectives: To access extent of oxidative stress developed by pesticides in pesticide sprayers of Satara
District.
Method: Forty pesticide sprayers having age group between 25-35 were selected in present study as subjects.
Control group comprised of healthy farmers of same age, not involved in spraying activity. Measurements
of anthropometry like height, weight and detail history were taken for each participant. Blood sample was
collected in plain bulb and serum was separated for the analysis of estimation of lipid peroxide by Kei Satoh
Method. Unpaired t test was used to find out level of significance by comparing mean and SD of both groups.
Results: There was significant rise in MDA (t= 14.09, P value <0.0001) in pesticide sprayers as compared
to controls.
Conclusions: Pesticides generate free radicals that damage the cell by altering cell permeability, energy
metabolism, intracellular and extracellular impairment in transport systems. All these results in development
of lipid peroxidation which damages various systems of human being

Author Biography

Gauri Joshi1, A.G. Joshi2, Ajit Sontakke3, Sangita Patil4, Dhirajkumar Mane4, K.C. Wingakar5

1PhD Student, Department of Physiology, 2Professor, 5Professor and HOD, Department of Physiology, 3Professor
& HOD, 4Associate Professor, Department of Biochemistry, Krishna Institute of Medical Sciences, Karad,
Maharashtra-415539 India, 4 Statistician, Directorate of Research, Krishna Institute of Medical Sciences “Deemed
to be University”, Karad, Maharashtra, India

Published
2020-05-22
How to Cite
Gauri Joshi1, A.G. Joshi2, Ajit Sontakke3, Sangita Patil4, Dhirajkumar Mane4, K.C. Wingakar5. (2020). Pesticides: Slow but Silent Killer. Medico Legal Update, 20(2), 363-368. Retrieved from http://ijop.net/index.php/mlu/article/view/1131