The Effect of Astaxanthin Administration on Plasma Levels of Tumor Necrosis Factor-α and Palatine Tonsil Swab in Chronic Tonsillitis Patients

  • Sutji Pratiwi Rahardjo1, Abd. Azis Rola1, Abdul Qadar Punagi1, Muh Fadjar Perkasa1
Keywords: Chronic tonsillitis, Tumor Necrosis Factor-α (TNF-α), TNF-α levels, palatine tonsil swab, astaxanthin.

Abstract

Background: Chronic tonsillitis is chronic inflammation of the palatine tonsils which can be caused by the
presence of free radicals that stimulate the formation of pro-inflammatory cytokines such as Tumor Necrosis
Factor-α (TNF-α) and interleukin-6 (Il-6). Astaxanthin as an antioxidant and anti-inflammatory is thought to
reduce levels of proinflammatory cytokines.
Aim: To determine plasma levels of TNF-α and palatine tonsill smears in patients with chronic tonsillitis
before and after administration of astaxanthin.
Method: Research with clinical trial design. Thirty-one subjects who met the inclusion and exclusion
criteria in the Ear, Nose, Throat, Head and Neck Surgery clinic in Wahidin Sudirohusodo Hospital and
Network Hospital were given astaxanthin 4 mg/day for 14 days. Plasma TNF-α levels and palatine tonsile
smears were examined before and after administration of astaxanthin. Data were analyzed using SPSS 25th
version. The statistical tests used Paired-t test and Independent-t test.
Results: Thirty-one subjects can be followed until the end of the study. Astaxanthin 4 mg per day for 14 days
can reduce plasma TNF-α levels and palatine tonsil swab of patients with chronic tonsillitis (p <0.05), and
there is no significant difference in TNF-α levels between plasma and palatine tonsil swab both before and
after administration astaxanthin (p> 0.05).
Conclusion: Astaxanthin can reduce plasma TNF-α levels and palatine tonsil swab in chronic tonsillitis
patients.

Author Biography

Sutji Pratiwi Rahardjo1, Abd. Azis Rola1, Abdul Qadar Punagi1, Muh Fadjar Perkasa1

1Ear, Nose, Throat, Head and Neck Surgery Department, Medical Faculty Hasanuddin University,
Makassar-Indonesia

Published
2020-05-22
How to Cite
Sutji Pratiwi Rahardjo1, Abd. Azis Rola1, Abdul Qadar Punagi1, Muh Fadjar Perkasa1. (2020). The Effect of Astaxanthin Administration on Plasma Levels of Tumor Necrosis Factor-α and Palatine Tonsil Swab in Chronic Tonsillitis Patients. Medico Legal Update, 20(2), 419-423. Retrieved from http://ijop.net/index.php/mlu/article/view/1141