Primary Women Infertility and Thyroid Disorders
The study was conducted to explore the prevalence of thyroid autoimmune disorders among primary
infertile women. Hormonal and immunological serum markers were tested including: TSH, T3, T4, TPO Ab,
prolactin and Interleukin-6. Thyroid abnormalities were observed in 38.5% of the primary infertile women.
Thyroid autoimmunity was more prevalent among primary infertile women (9.6%) than pregnant (4.0%)
and non-pregnant (4.3%) fertile women, but with no significant difference. Presence of thyroid hormones
related clinical manifestation in infertile women was higher (26.9%) in comparison to pregnant fertile
women and non-pregnant fertile groups. Abnormalities in menstrual cycles were much higher in infertile
women (90.4%) than non-pregnant fertile women (27.7%). Serum level of IL-6 was with no significant
differences among all study groups. In conclusion, AITD has a minor participation in the thyroid disorder–
associated infertility and their menstrual abnormalities in comparison with the larger scale of the non-AITD
participation. No role for the IL-6 in the thyroid associated primary infertility in women was detected.