Is Irisin a Phenotypic Parameter in Over-Weight Women with Polycystic Ovary Syndrome?

  • Shaden M.H. Mubarak1, Hanaa Addai Ali2
Keywords: Polycystic ovary syndrome, PCOS, irisin, BMI, IR, HOMA-IR, lipid profile, myokines, anovulation, infertility


Polycystic ovary syndrome (PCOS) is the most public hormonal chaos and the causesthe infertility in
the women of reproductive age, offering a varied set of clinical parameters.Irisin had assumed to have a
duty in metabolic conditions and PCOS. However, the correlation between irisin and metabolic conditions
in PCOS is not clear.The purpose of this control cases study was to evaluate the plasma levels of Irisin
in women with overweight PCOS and its correlations with other phenotypes parameters of PCOS. The
study involved 90 PCOS women and 40 control healthy women. The PCOS womenwere diagnostic by
BMI as overweight. Statistical analysis was performed by using by the SAS (2012) program1.Chiefresults
measure was to determinethe plasma Irisin levels in overweight cases. In addition, some phenotypic and
anthropometric parametersincluding BMI, lipid profile, sex hormones, FBG, Insulin, and HOMA-IRhad
measured in groups of the study. Results offasting Irisin levels showed significantly elevated differences in
overweight PCOS women as compared to the levels in overweight control women(P<0.047).The plasma
Irisin levels in overweight PCOS womenshowed significantly positively correlated with BMI,FBG, HOMAIR,
FSH,lipid profile except HDLc and LH/FSH ratioexhibited significantly negatively correlated (P<0.01).
Even though there is as until now no proof for a causal association between irisin andPCOS, it is potential
that the alterations in Irisin concentrations maybe considered as a phenotype parameter for the diagnosis or
development of PCOS, and may act a new PCOS test to follow this syndrome under diverse management
of treatments.

Author Biography

Shaden M.H. Mubarak1, Hanaa Addai Ali2

1Post Graduate, College of Pharmacy, University of Kufa, Ira, 2Proffesor Dr. Department of Chemistry,
College of Science, University of Kufa, Iraq

How to Cite
Shaden M.H. Mubarak1, Hanaa Addai Ali2. (2020). Is Irisin a Phenotypic Parameter in Over-Weight Women with Polycystic Ovary Syndrome?. Medico Legal Update, 20(2), 455-460. Retrieved from