Evaluation of Serum and Urinary Neutrophil Gelatinase Associated Lipocalin (NGAL) in Children with Nephrotic Syndrome
Background: Nephrotic syndrome in children is a common disease in the world, and is a group of clinical
symptoms and include (loss of protein in the urine, low protein level in the blood, the accumulation of fluid
in the body or edema, and high blood lipids). The cause of Nephrotic Syndrome is unknown. Neutrophil
gelatinase associated lipocalin is a protein encoded in humans by the LCN2 gene. NGAL interferes with
natural immunity by blocking iron, causing the growth of germs to be reduced. It is expressed in kidney,
prostate, respiratory and digestive cells. NGAL is used as a vital guide to kidney injury.
Method: Neutrophil gelatinase-associated lipocalin concentration was measured in blood plasma using
enzyme-linked immunosorbent assay (ELISA) and urine NGAL by Abbott i1000, measured plasma and
urine level of NGAL in 20 patients with steroid resistance nephrotic syndrome,20 patients with steroid
sensitive nephrotic syndrome, 17 patients with early diagnosed nephrotic syndrome compare with 20 healthy
volunteers enlisted as normal controls.
Results: Urine NGAL and plasma NGAL are significantly increase in SRNS, SSNS, EDNS compared with
Conclusion: NGAL can be used to diagnostic biomarker to predict steroid Sensitive or steroid resistance in
children with Nephrotic syndrome (NGAL is a differentiating marker between SSNS and SRNS).