Assessment of Serum Afamin and Preptin Levels as a Potential Diagnosis Markers for Cardiovascular Patients Undergoing Catheterization
The Cardiovascular disease (CVD) is a main cause of worldwide morbidity and mortality overwhelms any
of the circulatory system disease. Therefore, The aims of presented study were to assess whether an Afamin,
and Preptin levels are associated with Cardiovascular diseases; to find if there is an association between
Afamin and preptin levels with insulin resistance in progressive of patients with cardiovascular diseases
before and after treatment by catheterization.
A case-control study,comprised of 60 patients diagnosed as cardiovascular disease(30 male,30 female),
their ages ranged between 35-65 years old, and were matched with patients age and number of male and
female of 60 healthy control. The estimation of the levels of biochemical parameters in the patients and
control groups revealed a significant elevations (P <0.01) of the of Preptin (85.73±41.97 vs 41.58±23.50
pg/mL), Insulin (17.53±10.94 vs 6.89±4.71 μIU/mL), HOMA- IR (8.03 ± 4.85vs 2.39 ±0.82) in patients
before treatment by catheterization than the control group. But, they were significantly lower(P<0.01) in
Afamin level (1.59±0.36 vs 1.95±0.26) and HOMA-β (111.42±43.88 vs 145.58±36.51 pg/mL), in patients
before catheterization, when compared with healthy group. Furthermore, the result showed, significant
decreases (P<0.01) of Preptin (1.94±0.33 pg/mL) Insulin(9.99±3.62 μIU/mL), HOMA-IR (3.03 ± 1.21).
Also, were shown a significant increased (P<0.01) in level of Afamin in patients groups to (1.94±0.33
pg/mL) after treatment by catheterization. The result demonstrated that Afamin levels were a significant
negative correlation with preptin and HOMA-IR. On the other side the preptin levels revealed a significant
positively connected with BMI, Insulin and HOMA-IR.
The conclusions of the current study for the first time revealed that circulating Afamin and Preptin levels are
strongly involved in the progress of cardiovascular diseases and could independently predict pathogenesis
improvement of the of cardiovascular disease. They were associated with atherosclerosis disease that was
considered one of the most important leading causes of Cardiovascular disease.