Phenolic Compounds Role in Rat Immunity Changes that Caused by Entamoeba Histolytica

  • Shahad Abbas Ali Al-Attar1, Abeer Abbas Ali2
Keywords: E. histolytica; phenolic compounds; oxidative stress

Abstract

The present study was designed to show the potential role of phenolic compounds against the toxicity
of Entamoeba histolytica. The study used 20 adult male rats that distributed to four groups (each group
consist 5 rats); control group that received normal saline, second group rat injected intraperitoneal with E.
histolytica at dose 103 cyst/ml. third group rat injected intraperitoneal with E. histolytica at dose 103cyst/ml
and treated with 100ug/ml of phenolic compoundsfor four weeks. Fourth group rat injected intraperitoneal
with E. histolytica at dose 103cyst/ml and treated with 250ug/ml of phenolic compoundsfor four weeks. The
results show high significant increased (P < 0.05) in levels of Interferon gamma (INF-γ) and Tumor necrosis
factor-α (TNFα) in group that injected with E. histolytica compared with control group. About oxidative
stress, Levels of Malondialdehyde (MDA), Glutathione (GSH) and catalase show high significant changes
(P < 0.05) in group that injected with E. histolytica compared with control group. After using phenolic
compounds, levels of INF-γ, TNF-α MDA, GSH and catalase in treated groups show non-significant changes
(P < 0.05) compared with control group. It was concluded that phenolic compounds have been potential role
against E. histolytica.

Author Biography

Shahad Abbas Ali Al-Attar1, Abeer Abbas Ali2

1Ph.D in Parasitology, Veterinary Medicine College, Kirkuk University, Iraq, 2Ph.D in Parasitology,
Technical College of Kirkuk, Northern Technical University, Iraq

Published
2020-05-22
How to Cite
Shahad Abbas Ali Al-Attar1, Abeer Abbas Ali2. (2020). Phenolic Compounds Role in Rat Immunity Changes that Caused by Entamoeba Histolytica. Medico Legal Update, 20(2), 497-501. Retrieved from http://ijop.net/index.php/mlu/article/view/1156