The Association of Lipoprotein-a Levels, Neutrophil Lymphocyte Ratio and Hypertension with the Clinical Severity Scale Measured by NIHSS Scale in Patients with Acute Thrombotic Stroke

  • Muhammad Hamdan, Moh. Hasan Machfoed, Paulus Sugianto, A. Firdaus Sani, Moh Saiful Ardhi, Fadil
Keywords: Lipoprotein-a, Lymphocyte Neutrophil Ratio, Hypertension, NIHSS, Stroke

Abstract

Background: The correlation between levels of Lipoprotein-a, Neutrophil Lymphocyte Ratio and
hypertension with clinical severity scale remains a controversial issue.
Objective: To determine the correlation of levels of Lipoprotein-a, Neutrophil Lymphocyte Ratio and
hypertension with the severity scale measured by NIHSS scale in patients with acute thrombotic stroke.
Method: Lipoprotein-a levels, Neutrophil Lymphocyte ratio, blood pressure in patients with acute thrombotic
stroke were measured and clinical severity scale was assessed by NIHSS scale. The levels of lipoprotein-a
were grouped into normal and high levels of lipoprotein-a, Lymphocyte Neutrophil Ratios were grouped
into low and high and hypertension were grouped into stage 1 and 2. The data was analyzed using logistic
regression.
Results: There were 40 patients consisting of 29 (72.50%) male patients and 11 (27.50%) female patients.
The demographic data included gender, age, LDL level, random blood sugar level, diabetes mellitus status
and smoking status which were all homogeneous in both groups of lipoprotein-a, Neutrophil Lymphocyte
ratio and hypertension stage. In the logistic regression analysis, the lipoprotein-a and neutrophil lymphocyte
ratio were correlated with clinical severity scale (p = 0.018, RO 0.122 (CI 95% 0.022-0.696) vs p = 0.041,
RO 0.068 (95% CI 0.005-0.895) while hypertension stage was not correlated with clinical severity scale (p
= 0.97, RO 1.02 (95% CI 0.28-3.80).
Conclusion: The levels of lipoprotein-a and lymphocyte neutrophil ratio were related to the clinical severity
measured by NIHSS scale but not with hypertension

Author Biography

Muhammad Hamdan, Moh. Hasan Machfoed, Paulus Sugianto, A. Firdaus Sani, Moh Saiful Ardhi, Fadil

Department of Neurology, Faculty of Medicine,
Dr. Soetomo Teaching Hospital Surabaya-Universitas Airlangga 60285, Indonesia

Published
2020-05-22
How to Cite
Muhammad Hamdan, Moh. Hasan Machfoed, Paulus Sugianto, A. Firdaus Sani, Moh Saiful Ardhi, Fadil. (2020). The Association of Lipoprotein-a Levels, Neutrophil Lymphocyte Ratio and Hypertension with the Clinical Severity Scale Measured by NIHSS Scale in Patients with Acute Thrombotic Stroke. Medico Legal Update, 20(2), 658-663. Retrieved from http://ijop.net/index.php/mlu/article/view/1187