Structural Non-Structural Protein-1 Virus Dengue of Risk Factors on Functional Interference Hepar

  • Susilowati Andajani
Keywords: Non-structural protein 1, Hepatic function disorder, Dengue virus infection

Abstract

The causes of hepatic damage to DHF are mixed. Dengue virus can infect the liver and cause damage.
Histopathology of the liver in cases of fatal dengue shows that hepatocytes and Kupffer cells can be the
target of viral replication and there is involvement of apoptotic mechanism. This study aims to determine
the association between dengue virus NS1 protein and degree of clinical manifestation of dengue infection
with hepatic dysfunction. Blood samples after taking the serum, were examined for dengue virus NS1
protein and SGOT and SGPT examinations at the Surabaya Health Laboratory Center. Data analysis used
Chi Square, Fisher's Exact, Anava and Dunnet (a = 0.05). The results shows that the correlated variable
significantly with dengue hemorrhagic manifestation degree was dengue virus NS protein1 (p = 0.047),
with correlation strength of 26.8%. Variables significantly correlated with liver dysfunction were degree
of clinical manifestation of dengue fever (p = 0.037) with correlation strength of 33.5% and dengue virus
NS protein1 (p = 0.023) with correlation strength of 29.3%. There was a significant relationship between
the presence of dengue virus NS1 protein and the incidence of DHF. There was a significant relationship
between the presence of dengue virus NS1 protein with hepatic dysfunction (SGOT and SGPT) in dengue
virus infection.

Author Biography

Susilowati Andajani

Department of Public Health Science and Preventive Medicine, Faculty of Medicine,
Universitas Airlangga, Surabaya (60131), Indonesia

Published
2020-05-22
How to Cite
Susilowati Andajani. (2020). Structural Non-Structural Protein-1 Virus Dengue of Risk Factors on Functional Interference Hepar. Medico Legal Update, 20(2), 796-800. Retrieved from http://ijop.net/index.php/mlu/article/view/1213