Identifying and Revealing Active Compound from Green Tea (Camellia sinensis) for Curing Systemic Lupus Erythematosus by Acting as CASPASE 1 Inhibitor

Authors

  • Herin Mawarti1,5, Jusak Nugraha2 , Djoko Agus Purwanto3 , Joewono Soeroso 4

DOI:

https://doi.org/10.37506/mlu.v20i3.1439

Keywords:

Camellia sinensis, anti-apoptosis, pyroptosis, Systemic Lupus Erythematosus

Abstract

This research aimed to reveal the potency of green tea (Camellia sinensis) as immunomodulator, anti

apoptosis agent and anti pyroptosis agent in Systemic Lupus Erythematosus.. The rest samples was

downloaded from KNAPSACK Database. Biological activity prediction was conducted by PASS SERVER.

Molecular Docking analysis was performed by Autodock Vina in PyRx software v.0.9.3. Complex docking

was analyzed and visualized using Discovery Studio Software. The result showed that Camellia sinensis

has the main potency as immunomodulatory, antioxidant and anti-inflammation. The highest activity of this

herbal is antioxidant. There are few bioactive that have role as immunomodulator. The result of molecular

docking can explain the mechanism of active compound as anti-apoptosis and anti-pyroptosis. Docking

result showed that Theaflavin has the highest affinity to both activities. It can be concluded that bioactive

from Camelia sinensis is promising for curing Systemic Lupus Erythematosus by acting as antioxidant and

inhibit apoptosis and pyroptosis mechanism.

Author Biography

Herin Mawarti1,5, Jusak Nugraha2 , Djoko Agus Purwanto3 , Joewono Soeroso 4

1 Doctoral Program of Medical Science, Faculty of Medicine, Airlangga University, Indonesia, 2 Department

of Clinical Patology, Faculty of Medicine, Airlangga University, Indonesia, 3Department of Pharmaceutical

Chemistry, Faculty of Pharmacy, Airlangga University, Indonesia, 4 Department of Internal Medicine, Faculty

of Medicine, Airlangga University, Indonesia, 5 Department of Nursing Science, Faculty of Health Sciences,

University of Pesantren Tinggi Darul Ulum, Jombang, Indonesia

Published

2020-07-24

How to Cite

Herin Mawarti1,5, Jusak Nugraha2 , Djoko Agus Purwanto3 , Joewono Soeroso 4. (2020). Identifying and Revealing Active Compound from Green Tea (Camellia sinensis) for Curing Systemic Lupus Erythematosus by Acting as CASPASE 1 Inhibitor. Medico Legal Update, 20(3), 457-463. https://doi.org/10.37506/mlu.v20i3.1439