Identifying and Revealing Active Compound from Green Tea (Camellia sinensis) for Curing Systemic Lupus Erythematosus by Acting as CASPASE 1 Inhibitor
Keywords:Camellia sinensis, anti-apoptosis, pyroptosis, Systemic Lupus Erythematosus
This research aimed to reveal the potency of green tea (Camellia sinensis) as immunomodulator, anti
apoptosis agent and anti pyroptosis agent in Systemic Lupus Erythematosus.. The rest samples was
downloaded from KNAPSACK Database. Biological activity prediction was conducted by PASS SERVER.
Molecular Docking analysis was performed by Autodock Vina in PyRx software v.0.9.3. Complex docking
was analyzed and visualized using Discovery Studio Software. The result showed that Camellia sinensis
has the main potency as immunomodulatory, antioxidant and anti-inflammation. The highest activity of this
herbal is antioxidant. There are few bioactive that have role as immunomodulator. The result of molecular
docking can explain the mechanism of active compound as anti-apoptosis and anti-pyroptosis. Docking
result showed that Theaflavin has the highest affinity to both activities. It can be concluded that bioactive
from Camelia sinensis is promising for curing Systemic Lupus Erythematosus by acting as antioxidant and
inhibit apoptosis and pyroptosis mechanism.