Effects of Onion Extract on Hepar Histopatology in AlloxanInduced Diabetic Rattus Novergicus
Keywords:Allium ascalonicum, alloxan, liver, Rattus norvegicus.
This study was aimed to know the effect of giving shallot extract (Allium ascalonicum L) to histopathological
feature of rat (Rattus norvegicus) liver induced by alloxan. Alloxan was intraperitoneally injected 120 mg/
kg BW (single dose). A total of twenty male Wistar rats of three months old were used in the study. The rats
were divided into five groups. 1) negative control group (K-) treated by CMC Na 0.5 %, 2) positive control
group (K+) treated by metformin 45 mg/kg BW as a standard drug, 3) extract of Allium ascalonicum 250
mg/kg BW (P1), 4) extract of Allium ascalonicum 500 mg/kg BW (P2), 5) extract of Allium ascalonicum
750 mg/kg BW (P3). Rats were treated for 14 days. The data of this study were analyzed by Kruskal Wallis
Test, then it continued by Mann-Whitney Test. The result of this study is Allium ascalonicum can improve
the histopathological feature of rats liver induced by alloxan.