Effects of Two Different Doses of Vitamin B2 and a Single Dose of Vitamin B12 Against Cyclophosphamide Induced Nephrotoxicity
Keywords:Cyclophosphamide, Vitamin B2, Vitamin B12, Nephrotoxicity, Rats.
Cyclophosphamide, a medication that is used for the treatment of different types of cancer; however its’ use
associated with numerous adverse effects. Vitamin B2 and vitamin B12 suggested having nephroprotective
effect. This work is designed to investigate the nephroprotective effect of both vitamins against
cyclophosphamide induced nephrotoxicity. One hundred adult rats of both sexes were used in this study.
The animals were randomly enrolled into ten groups of 10 rats each. On day eight, animals were sacrificed
and blood collected for the measurement of serum superoxide dismutase 1, glutathione peroxidase; and
kidney extracted for histological examination. Vitamin B2 and vitamin B12 significantly (P<0.05) increase
superoxide dismutase 1, glutathione peroxidase; and the combination of vitamins produce significant
(P<0.05) increase in superoxide dismutase 1 and glutathione peroxidase compared to the corresponding
levels in other groups; and improve histopathological changes compared to cyclophosphamide-treated
rats. In conclusion both vitamins may have nephroprotective effects against cyclophosphamide-induced