Effects of Simvastatin and/or Metformin Administration on Lipid Profile and Reproductive Function in Adults Male Rats

Authors

  • Muhsin S.G. Al_Mozie’l l , Abbas A. Khudhair2 , Noora S. Ghalib3

DOI:

https://doi.org/10.37506/mlu.v20i3.1473

Keywords:

Metformin, Simvastatin, HMG-CoA reductase.

Abstract

Background : HMG-CoA reductase inhibitors, are large used lipid lowering medical that are effective in

the functions of male reproductive. In addition, Metformin is affected on level of cholesterol that results in

production of sperm. This study was designed to evaluate whether influence of simvastatin, metformin alone

and combination in male rats. Methods: In this experiment 24 adult male rats were randomly divided into four

groups(n=6) as following: control group (G1). 2nd group(G2)20 mg/kg simvastatin. 3rd group(G3)150mg/

kg of metformin. 4th group(G4)150mg/kg metformin + 20m/kg simvastatin. The administration rout by oral

gavage for 40 days. Results: There is a significant increase (P?0.05) in blood parameters, HDL cholesterol,

blood glucose, total protein and sperm abnormality in treated groups. Histopathological study of testes

reveals degeneration, vacuolation of germinal epithelium, destruction the wall of some seminiferous tubules.

Liver tissue shows dilated, congested sinusoid, vacuolation of hepatocytes and central vein congestion,

on the other hands, kidney reveals a vacuolation of some epithelial lining of glomeruli and renal tubules,

atrophy of some glomeruli and dilation of bowman`s capsules. Conclusion: Simvastatin have a better effect

on lipid profile. On the other hands, have more effects on testicular function.

Author Biography

Muhsin S.G. Al_Mozie’l l , Abbas A. Khudhair2 , Noora S. Ghalib3

1Lecturer/ Department of Pharmacology and Toxicology, College of Pharmacy. University of Basrah, Iraq,

2 Assistant Lecturer, 3 Assistant Lecturer/ Department of Clinical Laboratory Science, College of Pharmacy.

University of Basrah, Iraq.

Published

2020-07-24

How to Cite

Muhsin S.G. Al_Mozie’l l , Abbas A. Khudhair2 , Noora S. Ghalib3. (2020). Effects of Simvastatin and/or Metformin Administration on Lipid Profile and Reproductive Function in Adults Male Rats. Medico Legal Update, 20(3), 640-646. https://doi.org/10.37506/mlu.v20i3.1473