Effects of Simvastatin and/or Metformin Administration on Lipid Profile and Reproductive Function in Adults Male Rats
Keywords:Metformin, Simvastatin, HMG-CoA reductase.
Background : HMG-CoA reductase inhibitors, are large used lipid lowering medical that are effective in
the functions of male reproductive. In addition, Metformin is affected on level of cholesterol that results in
production of sperm. This study was designed to evaluate whether influence of simvastatin, metformin alone
and combination in male rats. Methods: In this experiment 24 adult male rats were randomly divided into four
groups(n=6) as following: control group (G1). 2nd group(G2)20 mg/kg simvastatin. 3rd group(G3)150mg/
kg of metformin. 4th group(G4)150mg/kg metformin + 20m/kg simvastatin. The administration rout by oral
gavage for 40 days. Results: There is a significant increase (P?0.05) in blood parameters, HDL cholesterol,
blood glucose, total protein and sperm abnormality in treated groups. Histopathological study of testes
reveals degeneration, vacuolation of germinal epithelium, destruction the wall of some seminiferous tubules.
Liver tissue shows dilated, congested sinusoid, vacuolation of hepatocytes and central vein congestion,
on the other hands, kidney reveals a vacuolation of some epithelial lining of glomeruli and renal tubules,
atrophy of some glomeruli and dilation of bowman`s capsules. Conclusion: Simvastatin have a better effect
on lipid profile. On the other hands, have more effects on testicular function.