Association of Terminal Complement Complex (TCC), Prostaglandin (PGj2) among Patient with First Episode Psychosis (Case-Control Study)
Keywords:first episode psychosis, serum Complement Complex C5b-9, Prostaglandin J 2. Psychosis.
The purpose of the study investigate the association between some inflammatory biomarkers with first
episode psychosis (FEP) and to find out the correlation with different socio demographic profile. A case
control study was involve patients with first episode psychosis and healthy control. peripheral Blood samples
collected from 44 cases they were attending AL-Hakeem General hospital, Psychiatric Department, Najaf,
Iraq, in the period between January, 2019 to may, 2019. The cases included females and males, and the
age was 18-70 years. Control: 44 healthy controls who had no history or clinical evidence of first episode
psychosis or any other disease. The result revealed that increase in the level of serum Complement Complex
C5b-9 and decrease Prostaglandin J-2 among FEP patients (1021.7±58.5 and 3.82±0.36) respectively in
comparison to control were mean (585.87±47.059 and 9.94±0.67). The results of this research concluded
that, the inflammatory response is an immune system that allow the individual to cope with various menacing
advise, but in long-lasting conditions and pathological, the continuous of this stimulate could develop into
harmful. The regulation of the all development involves endogenous counter-balancing mechanisms that
control special effects of deleterious pro inflammatory mediators. information showing a misbalance in
some pro inflammatory/anti inflammatory in blood of person with FEP.