Quinone Oxidoreductase 2 Serum Level that affecting the Psychotic Disorders of Methamphetamine Abusers

Authors

  • Dany H. Ludong1 , A. Jayalangkara Tanra2 , Mochammad Hatta3, Sonny T. Lisal4 , Ismail Fikri5 , Reza Nasution6 , Tri Supartini7

DOI:

https://doi.org/10.37506/mlu.v20i3.1496

Keywords:

Methamphetamine, Dopamine, NQO2 serum level, Methamphetamine Psychotic.

Abstract

Background: Some evidence suggests that genetic factors contribute to susceptibility to drug abuse such as

methamphetamin and that dopamine-quinone produced by dopamine might be involved in the mechanism

of symptoms associated with psychotic methamphetamine (MAP). Quinone detoxification is catalyzed

by a group of proteins, namely quinone oxidoreductase (NQO). In this study we analyzed serum NQO2

levels by examining ELISA Sandwich in clients who used methamphetamine. Methods: This research

is a Case-Control to determine the contribution of NQO2 to the emergence of psychotic disorders due

to methamphetamine abuse. The case group is residents who consume methamphetamine with psychotic

characteristics, while the control group is clients who consume methamphetamine without psychotic

characteristics Results: The mean value of NQO2 gene protein in the Elisa Sandwich examination for the

case group was lower than the value of the control group (1,246 < 3,657). The t test showed the value of

sig (Equal variances not assumed) = 0,000 that value is less than 0.05 (<0.05), this shows the difference in

the value of content protein NQO2 between the case group and the control group. Then the cut-off point

of the Receiver Operating Characteristic (ROC) curve in this study is recommended statistically between

1,960 and 2,165, meaning that if the expression value of protein content > 2.165 then the potential for

psychotic suffering is great, on the other hand if < 1.960, the potential is small for suffering from psychotics.

Conclusion: The protein content of the NQO2 gene in the Elisa Sandwich examination between the case

and control groups is different, the case group is lower than the control. While the CURVE ROC (Receiver

Operating Characteristic) Cut-Off value is recommended statistically between 1,960 and 2,165.

Author Biography

Dany H. Ludong1 , A. Jayalangkara Tanra2 , Mochammad Hatta3, Sonny T. Lisal4 , Ismail Fikri5 , Reza Nasution6 , Tri Supartini7

1 Doctor of Rehabilitation Center of Baddoka National Narcotics Agency, Makassar, 2Professor of Departement

of Psychiatry, Faculty of Medicine, Hasanuddin Univercity, Indonesia, 3Professor of Department of Moleculer

Biology and Immunology, Faculty of Medicine, Hasanuddin University, 4 Professor of Departement of Psychiatry,

Faculty of Medicine, Hasanuddin Univercity, 5 Postgraduate School of Medicine Doctoral Study Program,

Hasanuddin University, 6Postgraduate School of Medicine Doctoral Study Program, Hasanuddin University,

7 Jaffray Bible College, Makassar, Indonesia

Published

2020-07-24

How to Cite

Dany H. Ludong1 , A. Jayalangkara Tanra2 , Mochammad Hatta3, Sonny T. Lisal4 , Ismail Fikri5 , Reza Nasution6 , Tri Supartini7. (2020). Quinone Oxidoreductase 2 Serum Level that affecting the Psychotic Disorders of Methamphetamine Abusers. Medico Legal Update, 20(3), 782-787. https://doi.org/10.37506/mlu.v20i3.1496

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