Estimation of Some Immunological and Biochemical in the Patients with Systemic Lupus Erythematosus in Males and Females in Baghdad

Authors

  • Dua’a Akram AL-Atabi1 , Bushra F. Hasan2 , Ali H. AL-Hafidh3

DOI:

https://doi.org/10.37506/mlu.v20i3.1529

Keywords:

SLE, ESR, hsCRP, ANA, anti dsDNA, FT3, FT4, TSH, antiTPO, VIDAS.

Abstract

Background: Systemic lupus erythematosus (SLE) is the prototypic multisystem autoimmune disease

caused by the mistakenly in the body immune system that attacks healthy tissue in many parts of the body.

Autoimmune thyroiditis (AT) is an organic-specific disease associated with production of a variety of

antibodies such as antinuclear antibodies, anti-double stranded DNA, anti-Ro antibodies and anti-cardiolipin

antibodies.

Methods: the study consist of 90 subjects from the both sexes were registered in this study.. The subjects

have been divided in to three groups, group one and group two represent the patient groups that include,

(30 SLE patients without taking steroid drugs group one (3male-27female) and 30 SLE patients with taking

steroid drugs group two (2male-28female) with age range (16-57)years and thirty healthy subjects regards

as a control (5male-25female)). Various clinical and laboratory parameters of SLE were measured for each

groups. Also thyroid function tests were measured, which included free T3, free T4 and TSH. Antimicrosomal

was measured for all groups were estimated by VIDAS method.

Results: the results showed thyroid disorders were common (23.33%%) in lupus patients. Hypothyroidism

was the commonest (13.33%) abnormality in SLE patients then hyperthyroidism (1.66%). At the same

time, the results showed significance decreasing (p<0.01) in level of FT3 in (G1 and G2) when compared

with the control group. Also, the results showed high significant decrease (p<0.01) in level of FT4 in (G2)

comparison with both groups (G1) and control group. But, The results showed no significant differences

(P<0.01) in level of TSH comparison with other studies groups included in the study. Further antiTPO a

significant increasing (p<0.01) in (G1) comparison with both groups (G2) and control group. Then this study

revealed a significance increasing of ESR, hsCRP, anti dsDNA, and ANA in both patients groups rather than

control group.

Author Biography

Dua’a Akram AL-Atabi1 , Bushra F. Hasan2 , Ali H. AL-Hafidh3

1 Post graduate/ MSc, 2Professor, Department of Chemistry, College of Science for Women, University of Baghdad,

Iraq, 3 Lecturer/PhD in College of Health And Medical Technology /Baghdad/Iraq

Published

2020-07-24

How to Cite

Dua’a Akram AL-Atabi1 , Bushra F. Hasan2 , Ali H. AL-Hafidh3. (2020). Estimation of Some Immunological and Biochemical in the Patients with Systemic Lupus Erythematosus in Males and Females in Baghdad. Medico Legal Update, 20(3), 972-978. https://doi.org/10.37506/mlu.v20i3.1529