The Nature of the Il17 Cytokine Response In Rabbits PrimeBoosted With Eschrchia Coli-Pseudomonas Aeruginosa Prototype Bacterin Combinations
Keywords:Bacterin, Combination,enhance ,Immune, interference ,inhibition.
The prototype E .coli - P. aeruginosa heat killed bacterin balanced and unbalanced bacterin combinations,as
well as monotypic E. coli and single P. aeruginosa bacterins were developed. They were prime-boosted
rabbits by homologous prime-boost protocols. At the end of the specific immune-priming protocols ,rabbits
were bleed, sera saved in 0.5 ml aliquots at -18C till testing due time.IL17 Eliza assay was done on the test
and control sera. Single strength balanced combined bacterin combination induced increase in the mean
IL17 concentration means as compared to monotypic, double balanced ,un-balanced bcterin combinations
and control. The other combinations were showing inhibition in IL17 concentration means than control .The
immune interference matched To as: one bacterin enhance the other, and one damp the other. Enhancement of
IL17 response single strength combination might be a promise for efficacy of such combination in regulation
and protection against natural or experimental infectious challenges .