Roles of Brain-Derived Neurotrophic Factor (BDNF) In Developing Jaw
Keywords:Brain derived neurotrophic factor, bone, embryogenesis, osteogenic cell, bone stem cell
Brain-derived neurotrophic factor (BDNF) recognized to be involved in differentiation and proliferation
of specialized cell such as osteoblast cell and endothelial cell. The study designed to identify the effect of
exogenous BDNF on development of jaw and on neural marker expression.
Twenty pregnant rats, ten rats injected (I.M) with 0.1 ml normal saline, other ten injected (I.M) with 0.1 ml
of BDNF. Rats were received three doses at intervals (0, 7, 14 day of gestation periods).The developmental
jaw of embryos in 16th and 18th intra-uterine life studied for histological and immune-histochemical
The results Illustrated an enhancement of bone development during proceeding embryonic periods for both
study groups .Moreover, the experimental group showed a significant differences in the mean of bone cell
count at 18th day in comparison to 16th day IUL, and in comparison to control. Results revealed a positive
expression of neuronal marker by proliferating nerve cells with a significant difference in comparison between
experimental and control. The study suggests that BDNF may contributed in promoting the differentiation of
bone cells and enhancement of bone formation with increasing in expression of neuron marker.