Evaluation of the Immune Response in Scabies Patient (Ordinary and Prisoners) Treated with Permethrin 5%
Keywords:Scabies,IL-4, IL-9, totalIgE.
Scabies is a common parasitic infection, caused by sarco-sarcoptes, the infection occurs when the Sarcoptes
penetrates the corneal layer of the skin, predominant pathological manifestations, through inflammatory and
allergic reactions to mite products.This study is designed to obtain the Evaluation of the immune response
in scabies patient (Ordinary and Prisoners) treated with Permethrin 5%.The study included (28)Ordinary
Scabies patients, (32) prisonersas well as a (30)healthy person as a control group. Blood samples were
collected from all studied groups Enzyme-linked immunosorbent assay (ELISA) was used to measure
Interleukine-4,IL-9 and total IgE.Results of the study showed that serum,IL-4 showed a significant (P?0.
0001) increasing in prisoners compared to ordinary patients and control groups(248.8±19.3vs.79.2±10.7pg/
ml),(248.8±19.3vs.73.9±5.5pg/ml)respectively,while IL-9 showed a significant (P? 0.001), increasing in
control compared to Ordinary Scabies patients group and prisoners (506.9±48.7vs.337.8±18.2 pg/ml),
(506.9±48.7 vs. 424.1±36.5 pg/ml) respectively in post- treatment, There was positive correlation between
(IL-4 and IgE).Levels of two cytokines (IL-4, and IL-9) were assessed in sera of Ordinary ScabiesPatients
and control group, IL-4 showed a significant (P?0. 0001) increasing in Ordinary Scabies comparedto control
group (92.5±7.0 vs. 73.9 ± 5.5pg/ml), respectively. While IL-9with asignificant decreasinglevel inOrdinary
Scabies patients compared to control group(97.8 ±18.8 vs. 506.9 ±48.7 pg/ml) in pre-treatment, level of
IgE were recorded in pre- treatment in ordinary patients and prisoners (314.8±37.5 vs. 17.8±3.7 IU/ml),
(372.7±37.5 vs. 17.8±3.7 IU/ml) respectively, were a significantly increasing (P=>0.05) as compared to
healthy control. In post- treatment IgE levels show a significantly lowering (P=>0.05), in prisoners than
Ordinary patients(14.5±1.7 vs. 33.3±2.4 IU/ml).