Linkage between Cariogenic Streptococcus Mutans and Atherosclerotic Plaques of Cardiovascular Disease Patients in Iraqi Population
Keywords:Cardiovascular disease, Biofilm, Cariogenic Streptococcus mutans, PCR; Universal 16S ribosomal-RNA and Serotype-specific primers genotyping.
This study was done to identify the correlation between cariogenic S. mutans and CVD patients of Iraqi
Materials and Method: Eighty six cardiovascular Iraqi patients between (24-70) years old were investigated
for their association with cariogenic S. mutans. Pathological samples of vascular and heart valve biopsies
and atherosclerotic plaques from the catheter tips of the diagnostic and therapeutic catheters of CVD patients
were analyzed with molecular PCR technique with two types of primers, 16s universal primer and S. mutans
serotype-specific primer sets genotyping was performed to determine the linkage between cariogenic S.
mutans and CVD patients in Iraqi population.
Results: DNA samples of cariogenic S. mutans was specified in 60 / 86(69.7%) of the enrolled cardiovascular
disease patients, distributed according to the gender between 42/60 (70 %) in males and 18/60 (30%) in
females and according to the age between 33/60(55 %) of the positive patients were at 24-60 years and 27/60
(45 %) of the positive patients were > 60 years old.