Synthesis and Antibacterial Evaluation of some New Pyrazole Derivatives
Keywords:Claisen 1,2-addition, chalcones, pyrazol, phenylcarbamoyl, isoindoline.
Ten new chalcones were prepared in three steps, firstly phthalic anhydride reacted with 4- amino
acetophenone to produce 2-(4-acetyl phenyl carbamoyl) benzoic acid (A1), secondly [2-(4-acetyl phenyl
carbamoyl) benzoic acid (A1)] suffers from the loss of a water molecule via reaction with (anhydrous
sodium acetate and acetic anhydride) to produce 2-(4-acetyl phenyl) isoindoline-1,3-dione (A2), thirdly this
compound condensed with various substituted benzaldehydes affording chalcones (A3- A12) were reacted
with hydrazine hydrate to produce pyrazole compounds (A13- A22).
The prepared compounds were characterized by determination of melting point, FT-IR and some of the
prepared compounds have been characterized by (1 H-NMR and 13C-NMR) techniques.