Impact of Serum level of L-Carnitine on Chitotriosidase in Women with Gestational Diabetes Compared to T2DM Pregnant & Non Pregnant Iraqi Women

Authors

  • Ali Khalaf Hasan1 , Shatha H. Ali2 , Wiqar Akram Hussein3

DOI:

https://doi.org/10.37506/mlu.v20i4.1966

Keywords:

L-Carnitine, Chitotriosidase, Gestational Diabetes, T2DM

Abstract

Background: Gestational diabetes (GDM) was defined as any degree of glucose intolerance that to be first
recognized during pregnancy, regardless of the degree of high blood sugar. L-Carnitine appeared to act as a
vitamin and thus termed as vitamin BT. Under certain conditions, the demand for carnitine may exceed an
individual’s capacity to synthesize it, making it a conditionally essential nutrient. Whereas, chitotriosidase is
chitinase family member enzyme, produced by activated macro phages. Enzymatic activity of chitotriosidase
increases significantly during the development of acute or chronic disorders.
Aim: The study involved estimating serum level of L-carnitine & activity of chitotriosidase in women
with gestational diabetes compared to type-2 diabetic pregnant & non pregnant Iraqi women. In addition to
assessing the possible impact of variations of serum level of carnitine on serum chitotriosidase activity in
the study groups.
Methodology: This is a case control study included seventy-five women whom attending the Al Alwaiya
Maternity Teaching Hospital/Baghdad-Iraq. The participants were selected of similar age consisted of three
groups: 25 pregnant women with gestational diabetes, 25 pregnant women with type 2 diabetes, and 25
healthy non pregnant women as a control. After the provision of the ethical approval from Ethics Committee
of the Collage of Pharmacy–University of Baghdad. The studied biochemical markers were: total HbA1c,
lipid profile, serumL-carnitine & chitotriosidase.
Results and Discussion: Data analysis for comparing the groups results (gestational diabetes, T2DM and
control) indicated significant variations among them considering serum carnitinelevels & chitotriosidase
activity. However, HbA1C levels were positively correlated with L-carnitineamong GDM pregnant
women, with highest levels compared to the control & T2DM pregnant women. However, serum carnitine
levels were significantly correlated with chitotriosidase activity among GDM pregnants specifically (r=-
0.813,p=0.0001).
Conclusion: Serum carnitine level was significantly lowered in T2DM pregnant women,as well as in pregnant
women with GDM, as being compared to healthy non pregnant women. Whereas, serum chitotriosidase
level were significantly elevated in women with GDM, in comparison to T2DM and controls, it’s activity is
negatively correlated with serum carnitine level.

Author Biography

  • Ali Khalaf Hasan1 , Shatha H. Ali2 , Wiqar Akram Hussein3

    1
    M.Sc. Studient, 2Prof. Department of Clinical Laboratory Science/College of Pharmacy-University of Baghdad,
    3
    Lecturer In Gynecology & Obstetrics/AL-kindi College Pf Medicine

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Published

2020-11-18

How to Cite

Impact of Serum level of L-Carnitine on Chitotriosidase in Women with Gestational Diabetes Compared to T2DM Pregnant & Non Pregnant Iraqi Women. (2020). Medico Legal Update, 20(4), 1045-1056. https://doi.org/10.37506/mlu.v20i4.1966

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