Levels of Some Cytokines in Iraqi Patients with Multiple Myeloma
DOI:
https://doi.org/10.37506/mlu.v20i4.2060Keywords:
Health, Iraqi patients; myeloma; cytokines.Abstract
Introduction: Multiple myeloma is hematological disease characterize by abnormal functioning plasma
cell result in deterioration in different organs include bone and kidneys in addition to other complications.
The study aimed to measure some cytokines in the serum and determined if there is possibility to use this
cytokines as predictor for the multiple myeloma.
Materials and Method: Blood samples was drowned from 58 patients and 24 sex and age match control,
serum then isolated and proper ELISA kit then used to determined level of ?2 microglobulin, interleukins-13,
19, and 38.
Result: The result demonstrated significant increase in ?2 microglobulin in patients compare to control
(1.347+0.714 vs. 0.913+0.253), p = 0.00, interleukin-13 significant increase in patients group compare
to control group (204.56+189.84 vs. 106.17+52.07), p=0.001, interleukin-19 non-significant increase in
patients group compare to control group (22.46+42.09 vs. 11.252+8.574), p= 0.211, interleukin-38 significant
increase in patients group compare to controls (60.087+54.131 vs. 26.791+21.382), p= 0.00.
Discussion: The results of this study indicate that IL-13 and 38 possible to use as predictor for the disease.
