Plasma CD4 Count and Duration ARV as a Predictor of Virological Failure Amongst AIDS Patients

Authors

  • Choirina Windradi1,2, Erwin Astha Triyono1,3, Musofa Rusli1,3

DOI:

https://doi.org/10.37506/mlu.v21i1.2303

Keywords:

Virological Failure, HIV, AIDS, ARV

Abstract

Background: The 90-90-90 strategy to overcome the HIV/AIDS (Human Immunodeficiency Virus/Acquired
Immunodeficiency Syndrome) epidemic in the world still has challenges because 20% of people live with
HIV/AIDS (PLWHA) received anti retroviral (ARVs) are at risk of virological failure. This study describes
and analyzes the factors that influence the occurrence of virological failure in AIDS patients who have taken
ARVs.
Method: A hospital based cross-sectional study and retrospective medical record review in Dr. Soetomo
Teaching Hospital Surabaya from January 2017 until December 2018. Virological failure is plasma viral
load greater than 1000 copies/ml.
Result: According to data analysis for each variable, we used a CD4 (Cluster of Differentiation) cut-off
of 134 cells/?l and ? 20.5 months for virological failure. There was a statistically significant relationship
between CD4 cell count 95% CI (1.33-11,281) p 0.010 and duration of ARV (1,396-11.78) 95% CI p 0.01.
Summation of total score from both variables has a p value <0.001 which means the total score of the two
variables is significant as a predictor of virological failure. The total area of the ROC curve is 73.6% with a
sensitivity of 81.5% and specificity of 44.4%.
Conclusion: The duration of ARV consumption and CD4 cell count have an effect and can be an initial
evaluation of the occurrence of virological failure.

Author Biography

Choirina Windradi1,2, Erwin Astha Triyono1,3, Musofa Rusli1,3

1Faculty of Medicine, Universitas Airlangga, Surabaya 60131, Indonesia, 2Senior resident of Department of
Internal Medicine, Faculty of Medicine- Dr. Soetomo Teaching Hospital, Universitas Airlangga, Surabaya 60131,
Indonesia, 3
Tutor of Tropic and Infection Department of Internal Medicine, Faculty of Medicine- Dr. Soetomo
Teaching Hospital, Universitas Airlangga, Surabaya 60131, Indonesia

Published

2021-01-09

How to Cite

Choirina Windradi1,2, Erwin Astha Triyono1,3, Musofa Rusli1,3. (2021). Plasma CD4 Count and Duration ARV as a Predictor of Virological Failure Amongst AIDS Patients. Medico Legal Update, 21(1), 192-197. https://doi.org/10.37506/mlu.v21i1.2303