Effect of Allogenic Omental Graft on Esophegotomy Incision in Dogs Models
Keywords:Allogenic Omental Graft, Esophegotomy Incision, Dogs Models.
The study aimed to evaluate the beneficial effect of allogenic omental graft on esophageal healing in dogs.
Twenty healthy male adult dogs were used they were randomly divided into two equal groups (control
group 10, treated group 10). Under aseptic technique 4 cm skin incision was made in the midline of the
cervical(ventral) of animal by scalpel, after that the incision was sutured immediately by polyglycolic acid
suture materials 0.3 USP used simple continous technique, and the omental graft extracted from same animals
by laprotomy piece of greater omentum was then placed over the oesophagotomy incision of the experiment
group and secured in place with tacks sutures, In the control group, the esophagotomy suture line was left
without graft. Esophageal healing process follow up 1,2 and 3 weeks post operation by histopathological
examination, the result display in treated group on the first week post operation development of collagen and
lamina properia contain congested blood vessels with epithelial regeneration. 2 weeks post operation show
the epithelium of the mucosa of the esophagus was formed by hyperplasia of squamous cells. The surface
of these epithelia was covered by keratin with present of bundle of collagen and fibroblasts. 3 weeks post
operation showed the epithelium of esophagus was covered by keratin, with the presence of blood capillaries
and also, there was lymphocytic infiltration in the lamina properia with RBC. The tunica muscularis was
consisting of skeletal muscle fibers, inner longitudinal, and outer circular, proliferation of fibroblast with
deposition of collagen, while in control group histopathological examination in the first week show The
epithelium of the esophagus was stratified squamous with the presence of keratin on its surface, 2 weeks
post operation show The mucosa of the esophagus consisted of stratified squamous epithelium with a keratin
layer on its surface. The lamina properia was composed of loose connective tissue with infiltration of many
WBC and blood vessels, 3 weeks post operation show the basal layer of epithelium had many folds which
are interdigitation with the underlying lamina properia, which appeared loose connective tissue with few
numbers of fibroblasts and lymphocytes, the healing of treated group better than control group.
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