The Role of P53 Serine 46, Burkitt Cell Lymphoma 2 (BCL-2), and Cysteinyl Aspartate Specific Proteinase 3 (Caspase 3) Proteins as Risk Factors in Abortion

Authors

  • Herlambang Herlambang1 , Firman F. Wirakusumah2 , Jusuf S. Effendi2 , Ida Parwati3 , Leri Septiani4 , Ahmad Faried5 , Hiroyuki Kuwano6

DOI:

https://doi.org/10.37506/mlu.v21i1.2331

Keywords:

Burkitt cell lymphoma, cysteinyl aspartate specific proteinase 3, risk factors in abortion

Abstract

An Incomplete abortion is one of the complications that often occur during pregnancy, but the biomolecular
mechanism is still unknown. It has proven to be an increase in apoptosis activity that is controlled by a
variety of proteins, including p53 Ser 46, Bcl-2, and caspase 3, in uteroplasenta and reproductive organs. The
aim of the study is to measure the level of protein p54 Ser 46, Bcl-2, and caspase 3 in abortion and normal
pregnancy. A case control study conducted in 38 cases of incomplete abortion and 38 normal pregnancies as
a control. The level of protein of Ser 46, Bcl-2, and caspase 3 examined by ELISA independent/Duplo. The
higher level of p53 Ser 46 (> 0,09 U/mL) led to higher risks of abortion with OR 8.52; 95% CI, 2.65 to 28.6.
The higher level of Bcl-2 led to higher risks of abortion with OR 3.75; 95% CI, 1.24 to 11.68. The higher
level of caspase 3 (> 7 mg/mL) and p53 Ser 46 (> 0,09 U/mL) led to higher risks of abortion with OR 71.15;
95% CI, 8.74 to 578.92; with the result of series p, p, 0.001; p < 0.008; and p = 0.001. Level of protein p53
Ser 46 and caspase 3 in abortion is higher than normal pregnancies, while the Bcl-2 protein levels in abortion
is lower than normal pregnancies.

Author Biography

Herlambang Herlambang1 , Firman F. Wirakusumah2 , Jusuf S. Effendi2 , Ida Parwati3 , Leri Septiani4 , Ahmad Faried5 , Hiroyuki Kuwano6

1
Senior Lecturer, Department of Obstetrics and Gynecology, Faculty of Medicine and Health Science, Universitas
Jambi/Raden Mattaher Hospital, Jambi, Indonesia, 2
Professor, Division of Fetomaternal, Obstetric and
Gynecology Department, Universitas Padjadjaran/Hasan Sadikin Hospital, Bandung, Indonesia, 3Professor,
Pathology Clinics Department, Universitas Padjadjaran/Hasan Sadikin Hospital, Bandung, Indonesia,
4Researcher, Obstetric and Gynecology Department, Universitas Padjadjaran/Hasan Sadikin Hospital, Bandung,
Indonesia, 5Associate Professor, Neurosurgery Department, Universitas Padjadjaran/Hasan Sadikin Hospital,
Bandung, Indonesia, 6Professor, Department of General Surgical Science, Gunma University, Graduate School of
Medicine, Japan

Published

2021-01-09

How to Cite

Herlambang Herlambang1 , Firman F. Wirakusumah2 , Jusuf S. Effendi2 , Ida Parwati3 , Leri Septiani4 , Ahmad Faried5 , Hiroyuki Kuwano6. (2021). The Role of P53 Serine 46, Burkitt Cell Lymphoma 2 (BCL-2), and Cysteinyl Aspartate Specific Proteinase 3 (Caspase 3) Proteins as Risk Factors in Abortion. Medico Legal Update, 21(1), 340-345. https://doi.org/10.37506/mlu.v21i1.2331

Most read articles by the same author(s)