The Predictive Value of Serum Progesterone and Estrogen Recepters as Diagnostic Tool for Premature Ovarian Failure

Abstract

Background: Premature ovarian insufficiency (POI) is a delicate medical problem in young women. This
condition is not unchangeable and permanent but is associated with intermittent and unpredictable ovarian
activity, resulting in low conception rate. Over the period of 8 years, the evaluation of secondary amenorrhea
was conducted in 90 patients below the age of 40 who wished to restore fertility and is characterized by
irregular or absent periods and reduced fertility. Symptoms include those associated with the natural
menopause (night sweats and vaginal dryness), and with the long-term adverse effects of estrogen deficiency
(osteoporosis and cardiovascular disease): The latter is believed to explain the shorter life expectancy
associated with POI.
Aim: To illustrate the predictive value of progesterone receptors (PRs), estrogen receptors (ERs), progesterone
(PRG), estradiol (E2), Lulilizing hormones (LH), Follicle stimulating hormones (FSH) and Anti mullerian
hormones (AMH) serum levels as diagnostic approach for POI.
Method: Sixty (60) women with idiopathic POF with thirty (30) women as control groups were included
in the study. Baseline investigation in all subjects included serum progesterone receptors(PRs), estrogen
receptors(ERs), progesterone (PRG), estradiol (E2), Lulilizing hormones (LH), Follicle stimulating
hormones (FSH) and Anti mullerian hormones (AMH) levels were estimated using appropriate assays in
biochemistry laboratory.
Results: There was statistically significant differences in the serum progesterone receptors, estrogen
receptors, progesterone, estradiol, LH, FSH and AMH in POI cases when compared with healthy control
(P=<0.05).
Conclusion: These results indicate that serum progesterone and estrogen receptors levels, is high in POI cases
as a result of lack progesterone and estradiol hormones as a result of loss negative feedback inhibition,this
result may be used to primary diagnosis of premature ovarian failure.