The Predictive Value of Osteocalcin, Granulin, Cathepsin K and Some Other Biomarkers in Women with Premature Ovarian Failure

Authors

  • Mahmood Khalil Ibraheem1 , Mutazsabahahmied2 , Firas Shawqi Algburi3, Amina Hamed Alobaidi4

DOI:

https://doi.org/10.37506/mlu.v21i1.2357

Keywords:

Premature ovarian failure, Vitamin D, parathyroidhormones. Osteocalcin, Granulin, Cathepsin k.

Abstract

Background: Premature ovarian failure (POF), often and misleadingly referred to as ‘premature menopause’,
is defined as a loss of ovarian activity before the age of 40 years and is characterized by irregular or absent
periods and reduced fertility. Symptoms include those associated with the natural menopause (night sweats
and vaginal dryness), and with the long-term adverse effects of estrogen deficiency (osteoporosis and
cardiovascular disease): the latter is believed to explain the shorter life expectancy associated with POF.
Aim: To determinethe predictive value of serum osteocalcin(OC), granulin(GRN), cathepsin k (CTK),
vitamin D, parathyroid hormones (PTH), calcium and phosphrus as biomarkers for POF.
Method: Sixty (60) women with idiopathic POF with thirty (30) women as control groups were included in
the study. Baseline investigation in all subjects included serum Osteocalcin(OC), granulin(GRN), cathepsin
k (CTK), vitamin D, parathyroid hormones (PTH), calcium and phosphrus levels were estimated using the
appropriate assays for each.
Results: The mean serum levels of Osteocalcin, Ganulin,Parathyroid hormones,vitamin D and phosphorus,
were significantly higher in women with POF,when compared to healthy controls (P=<0.05). However, mean
serum levels of cathepsin k and calcium in POF group were non significant differences,when compared to
healthy controls.
Conclusion: Osteocalcin and granulin serum levels may be used as new biomarker for the diagnosis of
premature ovarian failure.

Author Biography

Mahmood Khalil Ibraheem1 , Mutazsabahahmied2 , Firas Shawqi Algburi3, Amina Hamed Alobaidi4

1
Clinical Biochemistry Specialist, Tikrit University College of Medicine, Tikrit Iraq, 2Assistant Professor, Tikrit
University College of Medicine, Tikrit Iraq, 3
Assistant Professor, Tikrit University College of Science, Tikrit Iraq,
4Assistant Professor, Kirkuk University College of Veterinary Medicine, Kirkuk

Published

2021-01-09

How to Cite

Mahmood Khalil Ibraheem1 , Mutazsabahahmied2 , Firas Shawqi Algburi3, Amina Hamed Alobaidi4. (2021). The Predictive Value of Osteocalcin, Granulin, Cathepsin K and Some Other Biomarkers in Women with Premature Ovarian Failure. Medico Legal Update, 21(1), 486-489. https://doi.org/10.37506/mlu.v21i1.2357