Relation of Human Papilloma Virus Infection with Pre Malignant and Malignant Endometrial Lesions
Keywords:HPV, endometrial carcinoma, hyperplasia.
Endometrial carcinoma is the second most common gynecologic cancer worldwide. Hyperplasia is a
precursor to endometrioid adenocarcinoma. There are few studies on the association of HPV with endometrial
Aim of the Study: To determine the relation of HPV with premalignant and malignant endometrial lesions.
Patients and Method: This study achieved on a total number of 90 patients with histopathological
examination revealing endometrial hyperplasia in 30 patient, endometrial carcinoma in 30 patient in addition
to 30 cases who underwent hystrectomy, for all patients detection of HR-HPV done by RT-PCR.
Results: The HR-HPV positivity was recorded in 23 patients. For the studied cases with endometrial
carcinoma, endometrial hyperplasia and controls the positivity rates were about (16.7%), (36.7%) and
(23.3%) respectively. Highest rate of HR-HPV positivity for the studied patients was found in the age group
(45-49). Highest rate of HR-HPV positivity in cases with endometrial carcinoma was reported in older age
groups [(45-49) and (50-54)], compared to endometrial hyperplasia and controls [(40-44) and (45-49)]. The
HR-HPV positivity was most frequently observed in cases with well-differentiated (22.2%). Higher HRHPV positivity rate was reported in the hyperplasia without atypia.
Conclusion: No role of HR-HPV in the pathogenesis of endometrial carcinoma.
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