Effect of Combined Antibiotics and Biofilm Formation in Some Bacterial Pathogens from Otitis Media among Children in Baghdad, Iraq
Keywords:Otitis media, Biofilm, Antibiotics, synergistic activity
Otitis media bacterial infections during childhood may contribute to the development of repeated
nasopharyngeal infections and it is complicated of recurrent or chronic middle ear diseases, especially with
multidrug resistant strains.
The results of antibiotic synergism for the most prevalent three bacterial species, isolated from otitis media
infections in children, and had the highest antibiotic resistance was revealed that combinations ceftazidimeamikacin and ceftazidime- ciprofloxacin displayed synergistic activity fractional inhibitory concentration
(FIC ? 0.5) against the most of tested isolates; Pseudomonas aeruginosa, Porteus mirabilis, and Klebsiella
pneumonia. In the biofilm test all tested isolates were showed biofilm production by tissue culture plate
method (TCP), in the present study, the strong biofilm production was most prevalent in Pseudomonas
aeruginosa (100%) followed by S. aureus (71.4%). Biofilm formation increases the activity of antibiotics
in children otitis media infections and using antibiotics combinations may be essential for optimum
management of OM patients.
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