Appraisal of Genotoxicity and Cytotoxicity of Depakine® and/ or Epanutin® in Bone Marrow Erythrocytes and Hepatocytes of Male Albino Mice by Comet and Micronucleus Assays
Keywords:Epilepsy, liver, mutagenicity, phenytoin, sodium valproate.
Background: Depakine and epanutin are widely used in the treatment of a variety of diseases. A special
attention should be given for their deleterious impacts on genetic material of patients.
Method: Sixty-five male albino mice were separated into four main sections. First is control injected with
normal saline 1ml/kg, second section injected with depakine 25 & 50 mg/kg/day, third section injected with
epanutin 3 & 6 mg/kg/day and fourth section injected with (depakine 25 + epanutin 3) & (depakine 50 +
epanutin 6) mg/kg/day. Injections were via intraperitoneal, samples of both bone marrow erythrocytes for
micronucleus test and hepatocytes for comet assay were collected after one and two weeks for each dose.
Conclusions: Human therapeutic doses range of depakine and/or epanutin generate (s) variable degrees
of damages in genetic material in both bone marrow erythrocytes and hepatocytes of male albino mice
depended on dose and time
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