Assessment of Neutrophil-to-Lymphocyte Ratio, Platelet-toLymphocyte Ratio,Oxidative Stress and Anti Oxidants levels in Polycystic Ovary Syndrome Patients with Low-Grade Chronic Inflammation
Keywords:Polycystic ovary syndrome, Inflammation, Oxidative Stress, Anti Oxidants.
Background: The ratio of neutrophils to lymphocytes (NLR) and the ratio of platelets to lymphocytes
(PLR)are prognostic factors in many diseases such as inflammatory diseases, cardiovascular diseases and
cancer. However, racing NLR and PLR are important, it is important to establish reference values for NLR
and PLR in polycystic ovary syndrome (PCOS) patients with mild chronic inflammation.
Objective: To determine the neutrophil-lymphocyte ratio (NLR)and platelet-lymphocyte ratio (PLR), and
the relationship between oxidative stress markers and anti oxidants markers in PCOS patients with lowgrade chronic Inflammation. Methodology. The study included 92 patients with PCOS and 46 control. Serum
PON1, XO, SOD activities, 8-OHdG and NO levels were measured using enzyme linked immunosorbent
assay (ELISA) kits.
Results: Concentration of TNF-?, IL-6, IL-8, IL-10 and CRP were significantly higher in PCOS patients
compared with control (P<0.001). Significant increases were recorded in WBC, ANC, PLT, NLR, PLR,
and ESR values. A significant decrease in ALC and MPV values in PCOS patients compared with control
(P<0.01). Serum XO, SOD activities and NOlevels were higher in PCOS patients than in the control
(p<0.001). Serum 8-OHdG levels and PON1 activities were lower in PCOS patients than in the control
(p<0.001). Serum CRP values is positively correlated with XO, NO, 8-OHdG and PON1 activity (r=0.377,
p<0.008; r=0.560, p<0.007; r=0.387, p<0.006; r=0.481, p<0.009), respectively. Serum CRP values is
negatively correlated with SOD activity in PCOS patients (r=?0.444, p<0.004).Serum XO activities were
negatively correlated with serum PON1 and SOD. Serum XO activities were Positively correlated with
serum NO and 8-OHdG levels.
Conclusion: Inflammation stimulates the oxidation process and reduces the ability of cellular antioxidants
in PCOS patients. NLR and PLR are good markers of inflammation, their highest values indicate the
severity of the disease and an imbalance between neutrophils and lymphocytes can be linked to cancer and
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