Using of Glycated Albumin Rather than Glycated Hemoglobin for assessing Glycaemic Control in Hemodialysis Patients with Type II Diabetes Mellitus

Abstract

Diabetes mellitus (DM) is a global epidemic that is correlated with long-term damage and causes dysfunction
of many organs like the kidney leading to diabetic nephropathy (DN) which need for heamodialysis (HD) to
protect progressive renal decline. This study was designed to evaluate the significance of glycated albumin
(GA), compared with fasting blood sugar (FBS) and glycated hemoglobin (HbA1c), were evaluated as an
indicator of glycemic control, also determinant of insulin. This study was conducted on 95 patients at age
rang (30-70) years, and patients include (35) HD patients with diabetes, (35) HD patients without diabetes
and (25) Type 2 diabetes mellitus, who attended atRamadi General Hospital and (25) samples as control
included in this study. This study showed that HbA1c% was significantly lower than simultaneous FBS and
GA% in HD patients in comparison with in diabetic patients and control, as illustrated in significantly shallow
slope of regression line between FBS with HbA1c and FBS with GA. Also, GA% was nearly corresponding
between before and after one hemodialysis in HD patients compared with HbA1c.In conclusion, GA provides
a better measure to estimate glycemic control in HD patients with diabetes compared with HbA1c.