Relationship of IL-6 Level and Lipid Profile as Predictor Ventilator-Associated Pneumonia
Keywords:Ventilator, IL-6, HDL, LDL, VAP
Background: Respiration support by mechanical ventilation is an important aspect in intensive care.
However, it could induce complication as infection. Ventilator Associated Pneumonia (VAP) is the most
common infection in patient with ventilator support. This infection have an impact to patient’s length of stay
and prognosis. VAP will be followed with inflamatory responses consist of elevation IL-6 level and lipid
profile abnormality. Therefore objective evaluation for acute inflamation could be a tool to diagnose VAP
Method: This study is analitic observational with prospektif design, to know the relationship of IL-6 dan
lipid profile (HDL and LDL) toward VAP incidence in 38 patient under Intensive Care treatment. Subject
observed for 7 days and IL-6, HDL,LDL levels were examined in the day with ventilator and 48 hours after
Result: VAP occur in 23 subject (65,53%) from all population. IL-6 (1), IL-6(2) and ? IL-6 levels have
significant effect to VAP incidence. HDL (1), HDL (2), LDL (1), and LDL (2) levels have significant effect to
VAP group. And ? HDL and ? LDL levels have significant effect to both group, VAP and non-VAP subjects.
Conclusion: IL-6, HDL and LDL level change have relation as predictor VAP incidence.
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