Relationship of IL-6 Level and Lipid Profile as Predictor Ventilator-Associated Pneumonia

Authors

  • Taufiq Gemawan1 , Arie Utariani2 , Kuntaman3

DOI:

https://doi.org/10.37506/mlu.v21i1.2461

Keywords:

Ventilator, IL-6, HDL, LDL, VAP

Abstract

Background: Respiration support by mechanical ventilation is an important aspect in intensive care.
However, it could induce complication as infection. Ventilator Associated Pneumonia (VAP) is the most
common infection in patient with ventilator support. This infection have an impact to patient’s length of stay
and prognosis. VAP will be followed with inflamatory responses consist of elevation IL-6 level and lipid
profile abnormality. Therefore objective evaluation for acute inflamation could be a tool to diagnose VAP
early.
Method: This study is analitic observational with prospektif design, to know the relationship of IL-6 dan
lipid profile (HDL and LDL) toward VAP incidence in 38 patient under Intensive Care treatment. Subject
observed for 7 days and IL-6, HDL,LDL levels were examined in the day with ventilator and 48 hours after
it.
Result: VAP occur in 23 subject (65,53%) from all population. IL-6 (1), IL-6(2) and ? IL-6 levels have
significant effect to VAP incidence. HDL (1), HDL (2), LDL (1), and LDL (2) levels have significant effect to
VAP group. And ? HDL and ? LDL levels have significant effect to both group, VAP and non-VAP subjects.
Conclusion: IL-6, HDL and LDL level change have relation as predictor VAP incidence.

Author Biography

Taufiq Gemawan1 , Arie Utariani2 , Kuntaman3

1
Resident of Department of Anesthesiology and Intensive Care, Faculty of Medicine, Airlangga University-Dr
Soetomo General Hospital, Mayjend Moestopo Street No. 6-8, Gubeng, Surabaya, East Java 60285, Indonesia,
2
Staff of Department of Anesthesiology and Intensive Care, Faculty of Medicine, Airlangga University-Dr Soetomo
General Hospital, Mayjend Moestopo Street No. 6-8, Gubeng, Surabaya, East Java 60285, Indonesia, 3
Staff of
Department of Clinical Microbiology, Faculty of Medicine, Airlangga University-Dr Soetomo General Hospital,
Mayjend Moestopo Street No. 6-8, Gubeng, Surabaya, East Java 60285, Indonesia

Published

2021-01-09

How to Cite

Taufiq Gemawan1 , Arie Utariani2 , Kuntaman3. (2021). Relationship of IL-6 Level and Lipid Profile as Predictor Ventilator-Associated Pneumonia. Medico Legal Update, 21(1), 1088-1092. https://doi.org/10.37506/mlu.v21i1.2461