Study of the Balance System between Some Enzymatic and Non-enzymatic Antioxidants in Blood Serum of Patients with Rheumatoid Arthritis in Mosul City, Iraq

Authors

  • Walaa A. Al-Jawadi1 Muna H. Jankeer2

DOI:

https://doi.org/10.37506/mlu.v21i1.2481

Keywords:

Rheumatoid arthritis, Antioxidants, Malondialdehyde, Glutathione Peroxidase.

Abstract

Rheumatoid arthritis (RA) is a chronic systemic inflammatory disease with an unknown etiology, which
effects on many tissues and organs. Therefore, the present study aimed to demonstrate the role of the
rheumatoid arthritis in causing oxidative stress by studying the level of balance between Malondialdehyde
MDA (as an indicator of oxidation) and non-enzymatic and enzymatic antioxidants in the blood serum
of 95 patients of both sexes, whose ages ranged between (18-74) years, as well as 50 healthy people of
both sexes and of the same ages of the injured, it was considered as a control group. The results showed
a significant increase (P?0.05) in the concentration of MDA in the serum of patients at 362% compared
with the healthy control group. While the results showed a significant decrease in the concentration of nonenzymatic antioxidants represented by glutathione GSH, albumin ?and uric acid in serum at 48%, 17% and
6% respectively, compared with control. The results also showed a significant decrease in the activity of the
enzymatic antioxidants represented by superoxide dismutase SOD and ceruloplasmin in the serum at 63%
and 10% respectively, while the activity of glutathione peroxidase GPX showed a significant increase by
44% compared with control. The results of the current study showed an increase in the rising or falling of
these studied variables more in female serum than males with RA. We conclude from this study a misalign of
balance system between oxidants and non- enzymatic and enzymatic antioxidants, which indicates that RA
disease caused oxidative stress in these patients, which leads to the long- term deterioration of the patient’s
condition.

Author Biography

Walaa A. Al-Jawadi1 Muna H. Jankeer2

1Lecturer, Professor, Optics Technologies Department, Al-Noor University College, Iraq,
2
Biology Department, Science College, Mosul University, Iraq

Published

2021-01-09

How to Cite

Walaa A. Al-Jawadi1 Muna H. Jankeer2. (2021). Study of the Balance System between Some Enzymatic and Non-enzymatic Antioxidants in Blood Serum of Patients with Rheumatoid Arthritis in Mosul City, Iraq. Medico Legal Update, 21(1), 1197-1201. https://doi.org/10.37506/mlu.v21i1.2481