Evaluating the Sensitivity of (miR-378) as a Circulatory Screening Biomarker for Diabetic Cardiomyopathy: Comparative Study

Abstract

Background: Diabetic cardiomyopathy is one of the serious complication of diabetes mellitus, with a silent
development and it is often underestimated, Currently available diagnostic techniques are limited in their
ability to identify patients who present with uncommon symptoms or silent myocardiopathy in its early
stages.
Aim: To evaluate role of miRNA-378 compared to GLS as a sensitive biomarker for early detection of
subclinical diabetic cardiomyopathy.
Method: The echocardiographic assessment for GLS was done for control group (H) and normotensive
diabetic patients and these patients were divided into (CD) group without cardiomyopathy, and (M)group
with cardiomyopathy diagnosed by negative GLS and positive GLS, respectively .Group (F) include
Hypertensive and/or ischemic diabetic patients with overt heart failure.
Results: There is significant elevation in miR-378 Ct value between H in one side & other three diabetic
gps. (CD, M, F) as presented in table (3-17) (p< 0.05). There is significant elevation in miR-378 Ct value in
M than CD groups. There is significant elevation in Ct value in F than M gp. (p=0.000). In the ROC curve
(AUC) was 0.965. The sensitivity and specificity were 0.978 and 0.646, respectively according to the chosen
cut-off value.
Conclusion: This study showed that miRNA-378 could be regarded as a novel sensitive biomarker which
could play a significant role for early detection of subclinical diabetic cardiomyopathy