Asprosin Role for Obese Male Patients with Diabetic Mellitus Type II

Abstract

Hormones, their receptors, and the associated signaling pathways make compelling drug targets because of
their wide-ranging biological significance to study the role of asprosin in obese male patients with diabetic
mellitus type II. ELISA method was used to assay asprosin and insulin. Blood was taken with drawn sample
from 30 obese normal patients with age range (40-60) years, 30 diabetic patients with age range (40-60)
years at duration of disease (1-5) years and 30 normal healthy patients. The mean difference between
T2DM according to insulin % (23.8±0.6) was increased than the mean of IFG (17.7±1.0) (P 0.000). The
mean difference between T2DM according to asprosin (122.1±21.8) was increased than the mean of IFG
(51.4±2.7) (P 0.000).the mean differences between DM2 and IFG cases in different weight groups (Ob.,
Ow. and Nw) according to insulin was studied, the results showed that, there were significant differences in
DM and IFG obese groups (G1 and G2) according to insulin (24.18±1.13, 15.56±0.66) P (0.00), however,
there were significant differences between DM and IFG in Normal weight groups (G5 and G6) according
to insulin (19.98±0.93, 11.12) P (0.00), while no significant differences between DM and IFG in Over
weight groups (G3 and G4) according to insulin (27.22±0.34,28.56±1.59) P (0.42).The mean differences
between diabetic mellitus type 2 and impaired fasting glucose cases in different weight groups (obese, over
weight and normal weight) according to Asprosin were shown in Table (3), Figure (). The results showed
that, there were significant differences between DM and IFG in obese groups (G1 and G2) according to
Asprosin (307.42±8.4, 66.3±2.2) P (0.00), However, there were significant differences between DM and IFG
in overweight groups (G3 and G4) according to Asprosin (28.3±0.5, 51.7±3.2) P (0.00) In addition to that,
there were significant differences between DM and IFG in normal weight groups (G5 and G6) according to
Asprosin (30.5±1.7, 21.2±1.6)