Frequency of Left Ventricle Dysfunction in non-Alcoholic Fatty Liver Disease (NAFLD) Patients Detected by Global Longitudinal Strain and Tissue Doppler Imaging in Babylon Province in Iraq

Abstract

The aim of the study is an assessment of left ventricle systolic and diastolic function in patients with nonalcoholic fatty liver disease (NAFLD) by measuring global longitudinal strain, and tissue Doppler imaging
TDI.
Method: A Case-control study enrolled 30 patients with non-alcoholic fatty liver disease (mean age 44.13
years) without a history of cardiac disease and 30 healthy controls (mean age 44.79 years). All participants
had been undergone trans-thoracic echocardiography (TTE), tissue Doppler imaging (TDI) for assessment
of mitral annular systolic velocity (S`), E/A ratio, and E/e’, as well as left ventricle global longitudinal strain
(GLS) using speckle tracking echocardiography (STE) technique.
Results: NAFLD patients had shown The E/e’ ratio was significantly higher in the NAFLD group (9.86±
1.69 vs 6.85 ±1.23),(P = < 0.001) . The difference in the E/A ratio between the groups was significant (P =
0.04). GLS was also significantly lower negative in NAFLD patients in comparison with control (-18.85±
1.07 vs -23.05 % ± 1.19) but within normal values.
Conclusion: There is an increasing risk of subclinical LV dysfunction (systolic and diastolic)in NAFLD
patientscan be early confirmed by DTI and GLS.