Levels of Some Biomarkers in Ischemic Heart Disease Patients
Keywords:sST2, IL-33, IHD, Stable angina, Unstable angina, Myocardial infarction.
The present study is an attempt to investigate the changes in serum soluble suppression of tumorigenicity 2
(sST2) and Interleukin-33 (IL-33) biomarkers levels in Iraqi ischemic heart disease(IHD) patients including
stable angina (SA), unstable angina (UA) and myocardial infarction (MI) compared to the healthy controls
(HC), and to evaluate the differences in these levels between these diseases combination groups. The
IHD’smortality surpass that of every major disease, so it is important that to get such research especially
among Iraqi patients. These biomarkers are expressed by myocardial cells, the sST2 is released when there
is a myocardial stress while the IL-33 has a cardio protective role, and both are expressed on atherosclerotic
plaque which is the most common cause of IHD. Collecting the blood samples from one hundred thirty
IHD patients with ages ranged (30-80) years, of both genders, excluding the patient with any autoimmune
disease, investigated for sST2 and IL-33 by ELISA technique. This study revealed that the sST2 was highly
significantly decreased in all IHD groups compared with HC; the 5% trimmed mean (ng/ml) was 8.48, 8.37,
9.31 versus 23.88 in SA, UA, MI and HC respectively; while the IL-33 was highly significantly decreased
in SA and UA groups while not significantly different in MI patients;the 5% trimmed mean (ng/L) was
969.93, 762.21, 1279.45 versus 2110 in SA, UA, MI and HC respectively. Also there was a significant direct
correlation between these biomarkers levels in all IHD groups.
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