Psoriasis Beyond Local Skin Disease

Authors

  • Amina Hamed Ahmed Alobaidi1 , Abdulghani Mohamed Alsamarai2 , Muhib Ahmed Salih3

DOI:

https://doi.org/10.37506/mlu.v21i1.2520

Keywords:

Psoriasis, Cholesterol, LDL, HDL, NHDL, MDA, Total antioxidant capacity.

Abstract

Background: Psoriasis is a skin disease that was associated with metabolic and clinical changes which
suggest that psoriasis is a systemic rather than local disease.
Aim: To illustrate whether psoriasis is local or systemic disease through analysis of some biomarkers.
Materials and Method: A 256 subjects with psoriasis and 221 sex and age matched controls were included
in the study. Serum total cholesterol [TC], high density lipoprotein [HDL], Malondialdehyde [MDA],
triglycerides [TG], and total antioxidant capacity [TCA] were determined using commercial kits.
Results: There were no significant differences between psoriasis and control groups in regards to mean
age and gender distribution, however, there was a significant difference [p<0.01] in BMI. Additionally, TC,
TG, LDL and NHDL were significantly higher [P<0.001] in patients with psoriasis than in controls, while
HDL was significantly lower in psoriasis than in controls. MDA mean serum level was significantly higher
[P<0.001] lower while TCA value was significantly [P<0.001] lower in subjects with psoriasis as compared
controls. Lipid profile rates and oxidation index were significantly higher in psoriasis than in controls, while
the anti-oxidation index was significantly lower in psoriasis.
Conclusion: These study findings suggest that psoriasis may be a systemic disease rather than local skin
disease.

Author Biography

Amina Hamed Ahmed Alobaidi1 , Abdulghani Mohamed Alsamarai2 , Muhib Ahmed Salih3

1
Assistant Professor, Department of Biochemistry, College of Veterinary Medicine, Kirkuk University Kirkuk,
2Professor, Depertmant of Medicine, College of Medicine, Tikrit University, Tikrit,, Iraq

Published

2021-01-09

How to Cite

Amina Hamed Ahmed Alobaidi1 , Abdulghani Mohamed Alsamarai2 , Muhib Ahmed Salih3. (2021). Psoriasis Beyond Local Skin Disease. Medico Legal Update, 21(1), 1409-1417. https://doi.org/10.37506/mlu.v21i1.2520

Most read articles by the same author(s)