Mammogenesis Effect of Hot Aqueous Extract of Mentha spicata Leaves on Mammary Tissue of Ovariectimized Rabbits

Abstract

Background: Plants are highly rich in phytochemicals being used to treat various conditions, and a rich
source of polyphenols is Spearmint (Mentha spicata L). Such polyphenols have demonstrated multiple
bioactivities. This study aims to investigate the effects of the intake of hot-aqueous extracts of spearmint
leaves on mammary gland development and growth
Method: Thirty six female rabbits were divided into two main groups (18 rabbits/group): (virgin and
lactating). Each group was further subdivided into three subgroups (Control, Ovariectomized (OVX) and
Spearmint, (6 rabbits/group).All three groups tissues were examined for histological, histochemical and
biochemical enzymatic analysis.
Result: Spearmint-treated ovariectimized virgin animals demonstrated an increase in the size of lobules that
affected the alveolar bud. In the ovariectimized lactating group treated with spearmint, it was shown that
the lobules were enlarged and produced more branching alveoli. The stain (PAS) and ALP showed positive
reaction in the spearmint group treated with lactation.
Conclusion: The hot methanol extract of the spearmint Mentha spicata leaves have a beneficial effect on
mammary gland growth and development.