The Role of Cell-Free Fetal DNA as a Preventative Attempt to Decrease the Severity of Genetic Disorders: A Review

Authors

  • Agung Sosiawan
  • Mala Kurniati
  • RM Coen Pramono D
  • Indra Mulyawan
  • Abdul Hadi Furqoni
  • Indah Nuraini
  • Qurrota A’yun

DOI:

https://doi.org/10.37506/mlu.v21i2.2638

Keywords:

Cell-free fetal DNA, Prenatal diagnosis, Genetic disorder.

Abstract

The development of prenatal diagnosis has developed very rapidly over decades. Prenatal screening is
applied to a mother with high-risk pregnancy (threatening the life of the fetus), such as a too-old mother or
a too-young mother and having a certain disease in her medical history. Up until now, the curative method
to treat genetic disorder is still developed and perfected. Therefore, a preventative action during pregnancy
is important to do, such as Noninvasive Prenatal Testing (NIPT). NIPT method that is widely developed
is the circulating cell-free fetal DNA (cffDNA) testing that can be useful for determining the fetal gender,
the identification of specific single-gene disorders, blood type, paternity determination, and the potency of
regular use for testing chromosomal abnormalities. The detection of cell-free fetal DNA in the maternal blood
circulation provides a new expectation for NIPT, especially preventing the severity of genetic disorders.

Author Biographies

Agung Sosiawan

Senior Lecterur, Department of Dental Public Health, Faculty of Dental Medicine, Universitas Airlangga,
Surabaya, Indonesia

Mala Kurniati

Post Graduate Doctoral Program, Faculty of Medicine, Universitas Airlangga, SurabayaIndonesia, Lecterur, Department of Biology, Faculty of Medicine, Universitas Malahayati, Lampung, Indonesia

RM Coen Pramono D

Professor, Department of Oral & Maxillofacial Surgery, Faculty of Dental Medicine, Universitas Airlangga,
Surabaya, Indonesia

Indra Mulyawan

Lecterur, Department of Oral & Maxillofacial Surgery, Faculty of Dental Medicine,
Universitas Airlangga, Surabaya, Indonesia

Abdul Hadi Furqoni

Researcher, Human Genetic and Forensic Laboratory, Institute of
Tropical Disease, Airlangga University, Surabaya, Indonesia

Indah Nuraini

Researcher, Human Genetic and Forensic Laboratory, Institute of
Tropical Disease, Airlangga University, Surabaya, Indonesia

Qurrota A’yun

Researcher, Human Genetic and Forensic Laboratory, Institute of
Tropical Disease, Airlangga University, Surabaya, Indonesia

Published

2021-03-12

How to Cite

Agung Sosiawan, Mala Kurniati, RM Coen Pramono D, Indra Mulyawan, Abdul Hadi Furqoni, Indah Nuraini, & Qurrota A’yun. (2021). The Role of Cell-Free Fetal DNA as a Preventative Attempt to Decrease the Severity of Genetic Disorders: A Review. Medico Legal Update, 21(2), 18-21. https://doi.org/10.37506/mlu.v21i2.2638

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