The Proteomic Expression of Nuclear Apoptosis-Inducing Factor1 (NAIF1) in Colorectal Tissues

Authors

  • Ahmed Arnaoty
  • Yves Bigot
  • Thierry Lecomt

DOI:

https://doi.org/10.37506/mlu.v21i2.2640

Keywords:

DNA transposons, Domestication, Neogene, NAIF1, microsatellite instable, microsatellite stable, colorectal cancer.

Abstract

The neogenic recombinases are potentially a source of genetic variability possibly implicated in the
mechanisms of genetic instability involved in the processes of carcinogenesis. One of these neogenic
recombinases is the nuclear apoptosis-inducing factor 1(NAIF1), which codes the protein NAIF1 that
induces apoptosis in various human cancers.
The aim of this work is to study the expression of NAIF1 neogene in cancerous and non-cancerous colorectal
tissues.
The protein expression of NAIF1gene has been studied by western blot method in the samples of protein
extracted from 29 patients with colorectal cancer.
The result of this study showed that the protein expression of NAIF1 was found in both cancerous and
non-cancerous colorectal tissues, but it is highly expressed in non-cancerous tissues adjacent to cancerous
one. Its expression is higher in non-metastatic cancerous tissues compared with metastatic one. Also this
expression is higher in microsatellite instable (MSI) group of cancer compared with microsatellite stable
(MSS) group.
It can be concluded that NAIF1 protein expression inversely related with more advanced stage or grade of
colorectal cancer and it may have a role in inhibition of proliferation, migration and invasion of colorectal
cancer by inducing apoptosis.

Author Biographies

Ahmed Arnaoty

Assistant Professor at Medenat AL-Elem University College Department of Nursing/Baghdad/Iraq

Yves Bigot

Director
of research at UMR INRA-CNRS 7247, INRA Val de Loire-France

Thierry Lecomt

Professor at Tours university, Department of
Hepato-Gastro-Enterology; Tours/France

Published

2021-03-12

How to Cite

Ahmed Arnaoty, Yves Bigot, & Thierry Lecomt. (2021). The Proteomic Expression of Nuclear Apoptosis-Inducing Factor1 (NAIF1) in Colorectal Tissues. Medico Legal Update, 21(2), 27-32. https://doi.org/10.37506/mlu.v21i2.2640