Characterization of NPM1 and FLT3-ITD Mutations in Iraqi Patients with AML

Authors

  • Hussam R Hamed
  • Rakad M.Kh AL-Jumaily
  • Areej E. Kadhom

DOI:

https://doi.org/10.37506/mlu.v21i2.2659

Keywords:

AML, NPM1, FLT3.

Abstract

Acute myeloid leukemia is a malignant disease results from mutation in a multipotent haemopoietic stem
cell. The study aimed to investigate NPM1 and FLT3-ITD mutations in Iraqi patients with AML and correlate
results with other clinical and laboratory findings. Fifty-eight AML patients, admitted to Baghdad Teaching
Hospital from October 2019 till March 2020 in addition to 25 normal controls, were included in the study.
A detailed history, laboratory investigations including FLT3-ITD and NPM1 mutations were collected from
and analyzed. FLT3-ITD was detected in 17.24% of patients, NPM1 mutation in 10.34%. Most of the
patients are presented with pallor. FLT3-ITD mutation had a higher blast cell count (74%) while NPM1
mutation had higher WBCs count.
Conclusion: AML is common in middle age group, patients with NPM1 mutation had significantly higher
WBCs count while patients with FLT3-ITD mutation have higher blast percentage compared with nonmutated patients.

Author Biographies

Hussam R Hamed

Scholar Researcher

Rakad M.Kh AL-Jumaily

Assistant Professor, Department of Biology, College of Science, University of Baghdad,
Baghdad, Iraq

Areej E. Kadhom

Scholar Researcher, Department of Laboratory, Baghdad Teaching Hospital, Medical City Center,
Baghdad, Iraq

Published

2021-03-12

How to Cite

Hussam R Hamed, Rakad M.Kh AL-Jumaily, & Areej E. Kadhom. (2021). Characterization of NPM1 and FLT3-ITD Mutations in Iraqi Patients with AML. Medico Legal Update, 21(2), 133-139. https://doi.org/10.37506/mlu.v21i2.2659

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