Study the Possible Levels of Inflammatory Marker TNF-? and Microalbuminuria in Type 2 Diabetic Nephropathy Patients of Babylon Province/Iraq
Keywords:Diabetic nephropathy, Microalbuminuria, TNF-α, Hypertension.
Background: Diabetic nephropathy is referred to as the kidney damage that occurs in people with diabetes developing it over many years characterized by gradually increasing urinary albumin excretion (>300µg/ mg) from microalbuminuria to proteinuria, blood pressure, and declining in glomerular filtration rate (GFR) (thickening in glomerulus) which represents the late event. Aim: Study the relationship between the levels of urinary TNF-? and the progression of diabetic nephropathy in type2 diabetic patients. Objective: Fasting blood and urine samples were collected from seventy type2 diabetic patients with enrollment the age, duration, blood pressure, and Body Mass Index (BMI) of each patient. the levels of urine TNF-? were established by ELISA. Results: forty-patients have normal albuminuria (Albumin/Creatinine Ratio <30 µg/mg) and only thirtypatients have microalbuminuria (Albumin/Creatinine Ratio>300 µg/mg) with increased urinary TNF-? levels. Conclusions: A significant positive relationship between urinary TNF-? and sever microalbuminuria.
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