Study the Possible Levels of Inflammatory Marker TNF-? and Microalbuminuria in Type 2 Diabetic Nephropathy Patients of Babylon Province/Iraq

Authors

  • Asma’a H. Mohamed
  • Haider K. Zaidan
  • Ali H. Al-Saadi

DOI:

https://doi.org/10.37506/mlu.v21i2.2676

Keywords:

Diabetic nephropathy, Microalbuminuria, TNF-α, Hypertension.

Abstract

Background: Diabetic nephropathy is referred to as the kidney damage that occurs in people with diabetes developing it over many years characterized by gradually increasing urinary albumin excretion (>300µg/ mg) from microalbuminuria to proteinuria, blood pressure, and declining in glomerular filtration rate (GFR) (thickening in glomerulus) which represents the late event. Aim: Study the relationship between the levels of urinary TNF-? and the progression of diabetic nephropathy in type2 diabetic patients. Objective: Fasting blood and urine samples were collected from seventy type2 diabetic patients with enrollment the age, duration, blood pressure, and Body Mass Index (BMI) of each patient. the levels of urine TNF-? were established by ELISA. Results: forty-patients have normal albuminuria (Albumin/Creatinine Ratio <30 µg/mg) and only thirtypatients have microalbuminuria (Albumin/Creatinine Ratio>300 µg/mg) with increased urinary TNF-? levels. Conclusions: A significant positive relationship between urinary TNF-? and sever microalbuminuria.

Author Biographies

Asma’a H. Mohamed

Lectural PhD. Department of Radiology Techniques-Al-Mustaqbal University College

Haider K. Zaidan

Prof. Dr. Department of
Scholarships and Cultural Relations, Ministry of Higher Education and Scientific Research, Baghdad-Iraq

Ali H. Al-Saadi

Prof.
Dr. Department of Biology-College of Science-University of Babylon

Published

2021-03-12

How to Cite

Asma’a H. Mohamed, Haider K. Zaidan, & Ali H. Al-Saadi. (2021). Study the Possible Levels of Inflammatory Marker TNF-? and Microalbuminuria in Type 2 Diabetic Nephropathy Patients of Babylon Province/Iraq. Medico Legal Update, 21(2), 218-222. https://doi.org/10.37506/mlu.v21i2.2676